| RRC ID |
56301
|
| 著者 |
Xu C, Li Q, Efimova O, He L, Tatsumoto S, Stepanova V, Oishi T, Udono T, Yamaguchi K, Shigenobu S, Kakita A, Nawa H, Khaitovich P, Go Y.
|
| タイトル |
Human-specific features of spatial gene expression and regulation in eight brain regions.
|
| ジャーナル |
Genome Res
|
| Abstract |
Molecular maps of the human brain alone do not inform us of the features unique to humans. Yet, the identification of these features is important for understanding both the evolution and nature of human cognition. Here, we approached this question by analyzing gene expression and H3K27ac chromatin modification data collected in eight brain regions of humans, chimpanzees, gorillas, a gibbon, and macaques. An analysis of spatial transcriptome trajectories across eight brain regions in four primate species revealed 1851 genes showing human-specific transcriptome differences in one or multiple brain regions, in contrast to 240 chimpanzee-specific differences. More than half of these human-specific differences represented elevated expression of genes enriched in neuronal and astrocytic markers in the human hippocampus, whereas the rest were enriched in microglial markers and displayed human-specific expression in several frontal cortical regions and the cerebellum. An analysis of the predicted regulatory interactions driving these differences revealed the role of transcription factors in species-specific transcriptome changes, and epigenetic modifications were linked to spatial expression differences conserved across species.
|
| 巻・号 |
28(8)
|
| ページ |
1097-1110
|
| 公開日 |
2018-1-1
|
| DOI |
10.1101/gr.231357.117
|
| PII |
gr.231357.117
|
| PMID |
29898898
|
| PMC |
PMC6071643
|
| MeSH |
Aged
Animals
Female
Gene Expression Profiling*
Gene Expression Regulation / physiology*
Hominidae
Humans
Macaca
Male
Middle Aged
Nerve Tissue Proteins / metabolism*
Transcription Factors / metabolism*
Transcriptome / physiology*
|
| IF |
11.093
|
| 引用数 |
22
|
| リソース情報 |
| GAIN |
id=376
id=428
id=252
id=441
id=332
id=442
id=572
id=574
id=1249 |
