RRC ID 56479
Author Higo A, Kawashima T, Borg M, Zhao M, López-Vidriero I, Sakayama H, Montgomery SA, Sekimoto H, Hackenberg D, Shimamura M, Nishiyama T, Sakakibara K, Tomita Y, Togawa T, Kunimoto K, Osakabe A, Suzuki Y, Yamato KT, Ishizaki K, Nishihama R, Kohchi T, Franco-Zorrilla JM, Twell D, Berger F, Araki T.
Title Transcription factor DUO1 generated by neo-functionalization is associated with evolution of sperm differentiation in plants.
Journal Nat Commun
Abstract Evolutionary mechanisms underlying innovation of cell types have remained largely unclear. In multicellular eukaryotes, the evolutionary molecular origin of sperm differentiation is unknown in most lineages. Here, we report that in algal ancestors of land plants, changes in the DNA-binding domain of the ancestor of the MYB transcription factor DUO1 enabled the recognition of a new cis-regulatory element. This event led to the differentiation of motile sperm. After neo-functionalization, DUO1 acquired sperm lineage-specific expression in the common ancestor of land plants. Subsequently the downstream network of DUO1 was rewired leading to sperm with distinct morphologies. Conjugating green algae, a sister group of land plants, accumulated mutations in the DNA-binding domain of DUO1 and lost sperm differentiation. Our findings suggest that the emergence of DUO1 was the defining event in the evolution of sperm differentiation and the varied modes of sexual reproduction in the land plant lineage.
Volume 9(1)
Pages 5283
Published 2018-12-11
DOI 10.1038/s41467-018-07728-3
PII 10.1038/s41467-018-07728-3
PMID 30538242
PMC PMC6290024
MeSH Cell Differentiation Chlorophyta / classification Chlorophyta / genetics Chlorophyta / growth & development Chlorophyta / metabolism Evolution, Molecular* Germ Cells, Plant / cytology* Germ Cells, Plant / metabolism Phylogeny Plant Proteins / genetics Plant Proteins / metabolism* Plants / classification Plants / genetics Plants / metabolism* Transcription Factors / genetics Transcription Factors / metabolism*
IF 12.121
Times Cited 9