Reference - Detail
| RRC ID | 56499 |
|---|---|
| Author | Davison JR, Bewley CA. |
| Title | Antimicrobial Chrysophaentin Analogs Identified from Laboratory Cultures of the Marine Microalga Chrysophaeum taylorii. |
| Journal | J Nat Prod |
| Abstract |
A laboratory culture of the colonial marine alga Chrysophaeum taylorii NIES-1699 yielded a set of new bioactive chrysophaentin analogs, and their structures were determined by HRESIMS and NMR spectroscopy. Differences in the metabolites identified between cultured C. taylorii NIES-1699 and field-collected strains from the U.S. Virgin Islands revealed additional structure-activity relationships for the Gram-positive antibiotic activity of the chrysophaentins. The presence of new hemichrysophaentins and a C-C linked biphenyl analog suggest novel features of their biosynthetic pathway. Bayesian analysis of the alignment of the 18S rRNA gene places the microalga C. taylorii in the pelagophyte clade. |
| Volume | 82(1) |
| Pages | 148-153 |
| Published | 2019-1-25 |
| DOI | 10.1021/acs.jnatprod.8b00858 |
| PMID | 30623657 |
| PMC | PMC8414558 |
| MeSH | Anti-Bacterial Agents / isolation & purification* Anti-Bacterial Agents / pharmacology Bayes Theorem Benzyl Compounds Biphenyl Compounds / isolation & purification* Biphenyl Compounds / metabolism Biphenyl Compounds / pharmacology Ethers, Cyclic Marine Biology Microalgae / metabolism* Structure-Activity Relationship |
| IF | 3.885 |
| Times Cited | 3 |
| Resource | |
| Algae | NIES-1699 |