| RRC ID |
56853
|
| Author |
Matsuo K, Haku A, Bi B, Takahashi H, Kamada N, Yaguchi T, Saijo S, Yoneyama M, Goto Y.
|
| Title |
Fecal microbiota transplantation prevents Candida albicans from colonizing the gastrointestinal tract.
|
| Journal |
Microbiol Immunol
|
| Abstract |
Gut microbes symbiotically colonize the gastrointestinal (GI) tract, interacting with each other and their host to maintain GI tract homeostasis. Recent reports have shown that gut microbes help protect the gut from colonization by pathogenic microbes. Here, we report that commensal microbes prevent colonization of the GI tract by the pathogenic fungus, Candida albicans. Wild-type specific pathogen-free (SPF) mice are resistant to C. albicans colonization of the GI tract. However, administering certain antibiotics to SPF mice enables C. albicans colonization. Quantitative kinetics of commensal bacteria are inversely correlated with the number of C. albicans in the gut. Here, we provide further evidence that transplantation of fecal microbiota is effective in preventing Candida colonization of the GI tract. These data demonstrate the importance of commensal bacteria as a barrier for the GI tract surface and highlight the potential clinical applications of commensal bacteria in preventing pathogenic fungal infections.
|
| Volume |
63(5)
|
| Pages |
155-163
|
| Published |
2019-5-1
|
| DOI |
10.1111/1348-0421.12680
|
| PMID |
30919462
|
| MeSH |
Animals
Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / pharmacology
Bacteria* / drug effects
Candida albicans / pathogenicity*
Candidiasis / prevention & control*
Fecal Microbiota Transplantation*
Gastrointestinal Microbiome* / drug effects
Gastrointestinal Tract / microbiology*
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Symbiosis
|
| IF |
1.442
|
| Times Cited |
2
|
| Resource |
| Pathogenic eukaryotic microorganisms |
IFM 60662 |
