論文 - 詳細
| RRC ID | 56863 |
|---|---|
| 著者 | Hara Y, Arai MA, Sakai K, Ishikawa N, Gonoi T, Yaguchi T, Ishibashi M. |
| タイトル | Dehydropropylpantothenamide isolated by a co-culture of Nocardia tenerifensis IFM 10554T in the presence of animal cells. |
| ジャーナル | J Nat Med |
| Abstract |
A new amide, named dehydropropylpantothenamide (1), was obtained by a co-culture of Nocardia tenerifensis IFM 10554T in the presence of the mouse macrophage-like cell line J774.1 in modified Czapek-Dox (mCD) medium. Compound 1 was synthesized from D-pantothenic acid calcium salt in 6 steps. The absolute configuration of natural compound 1 was determined by comparisons of the optical rotation and CD spectra of synthetic 1. In the present study, a new method for producing secondary metabolites was demonstrated using a "co-culture" in which the genus Nocardia was cultured in the presence of an animal cell line. |
| 巻・号 | 72(1) |
| ページ | 280-289 |
| 公開日 | 2018-1-1 |
| DOI | 10.1007/s11418-017-1161-y |
| PII | 10.1007/s11418-017-1161-y |
| PMID | 29209902 |
| MeSH | Animals Bacterial Proteins / genetics Biosynthetic Pathways Cell Line Coculture Techniques Host-Pathogen Interactions Macrophages / microbiology Mice Nocardia / genetics Nocardia / metabolism* Nocardia Infections / metabolism Nocardia Infections / microbiology Pantothenic Acid / analogs & derivatives* Pantothenic Acid / biosynthesis Pantothenic Acid / chemistry Pantothenic Acid / isolation & purification* Phylogeny |
| IF | 1.966 |
| 引用数 | 5 |
| リソース情報 | |
| 病原真核微生物 | 病原放線菌：IFM 10554 |