| RRC ID |
56864
|
| 著者 |
Kubota T, Nakamura K, Kurimoto SI, Sakai K, Fromont J, Gonoi T, Kobayashi J.
|
| タイトル |
Zamamidine D, a Manzamine Alkaloid from an Okinawan Amphimedon sp. Marine Sponge.
|
| ジャーナル |
J Nat Prod
|
| Abstract |
A new manzamine alkaloid, zamamidine D (1), was isolated from an Okinawan Amphimedon sp. marine sponge. The structure of zamamidine D (1) including the relative configuration was elucidated on the basis of spectroscopic data. Zamamidine D (1) is the first manzamine alkaloid possessing a 2,2'-methylenebistryptamine unit as the aromatic moiety instead of a β-carboline unit. Zamamidine D (1) showed antimicrobial activity against several bacteria and fungi.
|
| 巻・号 |
80(4)
|
| ページ |
1196-1199
|
| 公開日 |
2017-4-28
|
| DOI |
10.1021/acs.jnatprod.6b01110
|
| PMID |
28207259
|
| MeSH |
Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Animals
Carbazoles / chemistry
Carbolines / chemistry
Carbolines / isolation & purification*
Carbolines / pharmacology
Drug Screening Assays, Antitumor
Japan
Marine Biology
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera / chemistry*
|
| IF |
3.885
|
| 引用数 |
10
|
| リソース情報 |
| 病原真核微生物 |
病原真菌：IFM 62678, IFM 62679, IFM 62680, IFM 62681, IFM 2066 |
