| RRC ID |
56917
|
| Author |
Ishii M, Nishida S, Kataoka K, Nishiyama Y, Abe S, Sekimizu K.
|
| Title |
Lactic acid bacteria of the Leuconostoc genus with high innate immunity-stimulating activity.
|
| Journal |
Drug Discov Ther
|
| Abstract |
We screened lactic acid bacteria that exhibited high innate immunity-stimulating activity by monitoring muscle contraction activity in silkworms. Heat-treated fractions of lactic acid bacteria, Leuconostoc carnosum #7-2, Leuconostoc gelidum #4-2, and Leuconostoc mesenteroides 8/11-3, had high (250-460 units/mg) innate immunity-stimulating activity. These lactic acid bacteria proliferated in milk to concentrations of 1 × 106 colony forming unit/mL. The present findings suggest that the silkworm muscle contraction assay is useful for screening lactic acid bacteria with high innate immunity-stimulating activity, and that the assay can be used for the production of fermented foods made from milk.
|
| Volume |
11(1)
|
| Pages |
25-29
|
| Published |
2017-3-22
|
| DOI |
10.5582/ddt.2016.01078
|
| PMID |
28202882
|
| MeSH |
Adjuvants, Immunologic / pharmacology*
Animals
Bombyx
Immunity, Innate*
Leuconostoc / isolation & purification
Leuconostoc / physiology*
Milk / microbiology
|
| Times Cited |
4
|
| Resource |
| Silkworms |
|
