Reference - Detail
| RRC ID | 56919 |
|---|---|
| Author | Hamamoto H, Sekimizu K. |
| Title | [Development of Novel Antibiotic Lysocin E Identified by Silkworm Infection Model]. |
| Journal | Yakugaku Zasshi |
| Abstract |
In this symposium, we reported the identification and mechanistic analysis of a novel antibiotic named lysocin E. Lysocin E was identified by screening for therapeutic effectiveness in a silkworm Staphylococcus aureus infection model. The advantages of the silkworm infection model for screening and purification of antibiotics from the culture supernatant of soil bacteria are: 1) low cost; 2) no ethical issues; 3) convenient for evaluation of the therapeutic effectiveness of antibiotics; and 4) pharmacokinetics similar to those of mammals. Lysocin E has remarkable features compared with known antibiotics such as a novel mechanism of action and target. Here, we summarize our reports presented in this symposium. |
| Volume | 137(4) |
| Pages | 389-392 |
| Published | 2017-1-1 |
| DOI | 10.1248/yakushi.16-00235-4 |
| PMID | 28381711 |
| MeSH | Animals Anti-Bacterial Agents / pharmacokinetics Anti-Bacterial Agents / therapeutic use* Bombyx* Disease Models, Animal* Drug Evaluation, Preclinical / economics* Drug Evaluation, Preclinical / ethics* Peptides, Cyclic / pharmacokinetics Peptides, Cyclic / therapeutic use* Staphylococcal Infections / drug therapy* |
| IF | 0.286 |
| Times Cited | 1 |
| Resource | |
| Silkworms | |