論文 - 詳細
| RRC ID | 56926 |
|---|---|
| 著者 | Yagi A, Uchida R, Hamamoto H, Sekimizu K, Kimura KI, Tomoda H. |
| タイトル | Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
An in vivo-mimic silkworm infection model with Mycobacterium smegmatis was established. When silkworms were raised at 37 °C following an injection of M. smegmatis cells (1.25 × 107 CFU larva-1 g-1) into the silkworm hemolymph, they died within 48 h. Under these conditions, four microbial peptides with anti-M. smegmatis activity, lariatin A, calpinactam, lysocin E and propeptin, exerted therapeutic effects in a dose-dependent manner, and these are also clinically used agents that are active against Mycobacterium tuberculosis. These results indicate that the silkworm infection model with M. smegmatis is practically useful for the screening of therapeutically effective anti-M. tuberculosis antibiotics. |
| 巻・号 | 70(5) |
| ページ | 685-690 |
| 公開日 | 2017-5-1 |
| DOI | 10.1038/ja.2017.23 |
| PII | ja201723 |
| PMID | 28446822 |
| MeSH | Animals Anti-Bacterial Agents / pharmacology* Antitubercular Agents / administration & dosage Antitubercular Agents / pharmacology Bombyx Disease Models, Animal Dose-Response Relationship, Drug Microbial Sensitivity Tests Mycobacterium Infections, Nontuberculous / drug therapy* Mycobacterium Infections, Nontuberculous / microbiology Mycobacterium smegmatis / drug effects* Mycobacterium tuberculosis / drug effects Peptides / administration & dosage Peptides / pharmacology* |
| IF | 2.446 |
| 引用数 | 8 |
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