論文 - 詳細
| RRC ID | 56931 |
|---|---|
| 著者 | Tabuchi F, Matsumoto Y, Ishii M, Tatsuno K, Okazaki M, Sato T, Moriya K, Sekimizu K. |
| タイトル | Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus. |
| ジャーナル | J Antibiot (Tokyo) |
| Abstract |
We previously reported isolating vancomycin (VAN) highly resistant Staphylococcus aureus (VRSA) strains from clinical methicillin-resistant S. aureus strains by repeating steps of in vitro mutagenesis and VAN selection. Here we describe that the in vitro susceptibility of these VRSA strains to VAN was markedly increased by combined treatment with β-lactams such as ceftriaxone and oxacillin. Furthermore, in an in vivo silkworm infection model with VRSA, a combination of VAN and ceftriaxone exhibited therapeutic effects, whereas a combination of VAN and oxacillin did not. These findings suggest that combining VAN with an appropriate β-lactam, such as ceftriaxone, is therapeutically effective against infectious diseases caused by VRSA. |
| 巻・号 | 70(6) |
| ページ | 771-774 |
| 公開日 | 2017-6-1 |
| DOI | 10.1038/ja.2017.7 |
| PII | ja20177 |
| PMID | 28196977 |
| MeSH | Animals Anti-Bacterial Agents / administration & dosage Anti-Bacterial Agents / pharmacology* Bombyx Ceftriaxone / administration & dosage Ceftriaxone / pharmacology Disease Models, Animal Drug Synergism Microbial Sensitivity Tests Oxacillin / administration & dosage Oxacillin / pharmacology Staphylococcal Infections / drug therapy* Staphylococcal Infections / microbiology Staphylococcus aureus / drug effects* Vancomycin / administration & dosage Vancomycin / pharmacology* Vancomycin Resistance beta-Lactams / administration & dosage beta-Lactams / pharmacology* |
| IF | 2.446 |
| 引用数 | 5 |
| リソース情報 | |
| カイコ | |