論文 - 詳細
| RRC ID | 56954 |
|---|---|
| 著者 | Matsuzaki M, Mizushima S, Hiyama G, Hirohashi N, Shiba K, Inaba K, Suzuki T, Dohra H, Ohnishi T, Sato Y, Kohsaka T, Ichikawa Y, Atsumi Y, Yoshimura T, Sasanami T. |
| タイトル | Lactic acid is a sperm motility inactivation factor in the sperm storage tubules. |
| ジャーナル | Sci Rep |
| Abstract |
Although successful fertilization depends on timely encounters between sperm and egg, the decoupling of mating and fertilization often confers reproductive advantages to internally fertilizing animals. In several vertebrate groups, postcopulatory sperm viability is prolonged by storage in specialized organs within the female reproductive tract. In birds, ejaculated sperm can be stored in a quiescent state within oviductal sperm storage tubules (SSTs), thereby retaining fertilizability for up to 15 weeks at body temperature (41°C); however, the mechanism by which motile sperm become quiescent within SSTs is unknown. Here, we show that low oxygen and high lactic acid concentrations are established in quail SSTs. Flagellar quiescence was induced by lactic acid in the concentration range found in SSTs through flagellar dynein ATPase inactivation following cytoplasmic acidification ( |
| 巻・号 | 5 |
| ページ | 17643 |
| 公開日 | 2015-12-1 |
| DOI | 10.1038/srep17643 |
| PII | srep17643 |
| PMID | 26619826 |
| PMC | PMC4664960 |
| MeSH | Animal Structures / metabolism* Animals Female Hot Temperature Hydrogen-Ion Concentration Lactic Acid / metabolism* Male Quail / metabolism* Sperm Motility / physiology* Spermatozoa / metabolism* |
| IF | 3.998 |
| 引用数 | 18 |
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