論文 - 詳細
| RRC ID | 56967 |
|---|---|
| 著者 | Seki R, Li C, Fang Q, Hayashi S, Egawa S, Hu J, Xu L, Pan H, Kondo M, Sato T, Matsubara H, Kamiyama N, Kitajima K, Saito D, Liu Y, Gilbert MT, Zhou Q, Xu X, Shiroishi T, Irie N, Tamura K, Zhang G. |
| タイトル | Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features. |
| ジャーナル | Nat Commun |
| Abstract |
Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers. By analysing 48 bird genomes, we identified millions of avian-specific highly conserved elements (ASHCEs) that predominantly (>99%) reside in non-coding regions. Many ASHCEs show differential histone modifications that may participate in regulation of limb development. Comparative embryonic gene expression analyses across tetrapod species suggest ASHCE-associated genes have unique roles in developing avian limbs. In particular, we demonstrate how the ASHCE driven avian-specific expression of gene Sim1 driven by ASHCE may be associated with the evolution and development of flight feathers. Together, these findings demonstrate regulatory roles of ASHCEs in the creation of avian-specific traits, and further highlight the importance of cis-regulatory rewiring during macroevolutionary changes. |
| 巻・号 | 8 |
| ページ | 14229 |
| 公開日 | 2017-2-6 |
| DOI | 10.1038/ncomms14229 |
| PII | ncomms14229 |
| PMID | 28165450 |
| PMC | PMC5473641 |
| MeSH | Animals Biological Evolution* Birds / physiology* Datasets as Topic Dinosaurs / physiology Feathers / growth & development Flight, Animal / physiology* Gene Expression Regulation, Developmental / physiology Genome Histones / physiology Phylogeny Regulatory Sequences, Nucleic Acid / physiology* Transcription Factors / physiology Wings, Animal / growth & development* |
| IF | 11.878 |
| 引用数 | 28 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 89 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.5 |
| リソース情報 | |
| ニワトリ・ウズラ | |