Reference - Detail
| RRC ID | 57098 |
|---|---|
| Author | Wilcockson SG, Ashe HL. |
| Title | Drosophila Ovarian Germline Stem Cell Cytocensor Projections Dynamically Receive and Attenuate BMP Signaling. |
| Journal | Dev Cell |
| Abstract |
In the Drosophila ovarian germline, Bone Morphogenetic Protein (BMP) signals released by niche cells promote germline stem cell (GSC) maintenance. Although BMP signaling is known to repress expression of a key differentiation factor, it remains unclear whether BMP-responsive transcription also contributes positively to GSC identity. Here, we identify the GSC transcriptome using RNA sequencing (RNA-seq), including the BMP-induced transcriptional network. Based on these data, we provide evidence that GSCs form two types of cellular projections. Genetic manipulation and live ex vivo imaging reveal that both classes of projection allow GSCs to access a reservoir of Dpp held away from the GSC-niche interface. Moreover, microtubule-rich projections, termed "cytocensors", form downstream of BMP and have additional functionality, which is to attenuate BMP signaling. In this way, cytocensors allow dynamic modulation of signal transduction to facilitate differentiation following GSC division. This ability of cytocensors to attenuate the signaling response expands the repertoire of functions associated with signaling projections. |
| Volume | 50(3) |
| Pages | 296-312.e5 |
| Published | 2019-8-5 |
| DOI | 10.1016/j.devcel.2019.05.020 |
| PII | S1534-5807(19)30392-2 |
| PMID | 31178401 |
| PMC | PMC6688100 |
| MeSH | Animals Bone Morphogenetic Proteins / genetics Bone Morphogenetic Proteins / metabolism* Cell Differentiation Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster Female Gene Expression Regulation, Developmental Ovary / cytology* Signal Transduction* Stem Cell Niche* Stem Cells / cytology Stem Cells / metabolism* |
| IF | 9.19 |
| Times Cited | 3 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 50 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#109171 |