論文 - 詳細
| RRC ID | 57100 |
|---|---|
| 著者 | McLaughlin CN, Perry-Richardson JJ, Coutinho-Budd JC, Broihier HT. |
| タイトル | Dying Neurons Utilize Innate Immune Signaling to Prime Glia for Phagocytosis during Development. |
| ジャーナル | Dev Cell |
| Abstract |
Glia continuously survey neuronal health during development, providing trophic support to healthy neurons while rapidly engulfing dying ones. These diametrically opposed functions necessitate a foolproof mechanism enabling glia to unambiguously identify those neurons to support versus those to engulf. To ensure specificity, glia are proposed to interact with dying neurons via a series of carefully choreographed steps. However, these crucial interactions are largely obscure. Here we show that dying neurons and glia communicate via Toll-receptor-regulated innate immune signaling. Neuronal apoptosis drives processing and activation of the Toll-6 ligand, Spätzle5. This cue activates a dSARM-mediated Toll-6 transcriptional pathway in glia, which controls the expression of the Draper engulfment receptor. Pathway loss drives early-onset neurodegeneration, underscoring its functional importance. Our results identify an upstream priming signal that prepares glia for phagocytosis. Thus, a core innate immune pathway plays an unprecedented role setting the valence of neuron-glia interactions during development. |
| 巻・号 | 48(4) |
| ページ | 506-522.e6 |
| 公開日 | 2019-2-25 |
| DOI | 10.1016/j.devcel.2018.12.019 |
| PII | S1534-5807(18)31087-6 |
| PMID | 30745142 |
| PMC | PMC6394877 |
| MeSH | Animals Animals, Genetically Modified Apoptosis / physiology Brain / metabolism* Drosophila / metabolism Drosophila Proteins / metabolism Humans Membrane Proteins / metabolism Neuroglia / metabolism* Neurons / metabolism* Phagocytosis / physiology* |
| IF | 9.19 |
| 引用数 | 9 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#105471 |