Reference - Detail
| RRC ID | 57105 |
|---|---|
| Author | Yadav S, Younger SH, Zhang L, Thompson-Peer KL, Li T, Jan LY, Jan YN. |
| Title | Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. |
| Journal | Proc Natl Acad Sci U S A |
| Abstract |
Sensory neurons perceive environmental cues and are important of organismal survival. Peripheral sensory neurons interact intimately with glial cells. While the function of axonal ensheathment by glia is well studied, less is known about the functional significance of glial interaction with the somatodendritic compartment of neurons. Herein, we show that three distinct glia cell types differentially wrap around the axonal and somatodendritic surface of the polymodal dendritic arborization (da) neuron of the Drosophila peripheral nervous system for detection of thermal, mechanical, and light stimuli. We find that glial cell-specific loss of the chromatin modifier gene dATRX in the subperineurial glial layer leads to selective elimination of somatodendritic glial ensheathment, thus allowing us to investigate the function of such ensheathment. We find that somatodendritic glial ensheathment regulates the morphology of the dendritic arbor, as well as the activity of the sensory neuron, in response to sensory stimuli. Additionally, glial ensheathment of the neuronal soma influences dendritic regeneration after injury. |
| Volume | 116(11) |
| Pages | 5126-5134 |
| Published | 2019-3-12 |
| DOI | 10.1073/pnas.1814456116 |
| PII | 1814456116 |
| PMID | 30804200 |
| PMC | PMC6421456 |
| MeSH | Animals Axons / metabolism Axons / radiation effects Caspases / metabolism DNA Helicases / metabolism Dendrites / metabolism* Dendrites / radiation effects Drosophila Proteins / metabolism Drosophila melanogaster / metabolism* Enzyme Activation / radiation effects Light Neuroglia / metabolism* Neuroglia / radiation effects Sensory Receptor Cells / cytology* Sensory Receptor Cells / metabolism* Sensory Receptor Cells / radiation effects |
| IF | 9.58 |
| Times Cited | 2 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 9 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#105188 |