Reference - Detail
| RRC ID | 57124 |
|---|---|
| Author | Chai PC, Cruchet S, Wigger L, Benton R. |
| Title | Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system. |
| Journal | Nat Commun |
| Abstract |
Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-probe specific lineages, especially at early developmental stages prior to expression of unique molecular markers. Here, we use a genetic immortalization method to analyze the development of sensory neuron lineages in the Drosophila olfactory system, from their origin to terminal differentiation. We apply this approach to define a fate map of nearly all olfactory lineages and refine the model of temporal patterns of lineage divisions. Taking advantage of a selective marker for the lineage that gives rise to Or67d pheromone-sensing neurons and a genome-wide transcription factor RNAi screen, we identify the spatial and temporal requirements for Pointed, an ETS family member, in this developmental pathway. Transcriptomic analysis of wild-type and Pointed-depleted olfactory tissue reveals a universal requirement for this factor as a switch-like determinant of fates in these sensory lineages. |
| Volume | 10(1) |
| Pages | 643 |
| Published | 2019-2-7 |
| DOI | 10.1038/s41467-019-08345-4 |
| PII | 10.1038/s41467-019-08345-4 |
| PMID | 30733440 |
| PMC | PMC6367400 |
| MeSH | Animals Drosophila Drosophila Proteins / metabolism Olfactory Bulb / cytology* Olfactory Bulb / metabolism* Sensory Receptor Cells / cytology* Sensory Receptor Cells / metabolism* |
| IF | 11.878 |
| Times Cited | 3 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 25 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#105257 DGRC#104601 DGRC#108491 DGRC#108068 |