論文 - 詳細
| RRC ID | 57138 |
|---|---|
| 著者 | Yin C, Xi R. |
| タイトル | A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Cell Enteroendocrine Commitment in Drosophila. |
| ジャーナル | Stem Cell Reports |
| Abstract |
The intestinal epithelium in the Drosophila midgut is maintained by intestinal stem cells (ISCs), which are capable of generating both enterocytes and enteroendocrine cells (EEs) via alternative cell fate specification. Activation of Delta-Notch signaling directs ISCs for enterocyte generation, but how EEs are generated from ISCs remains poorly understood. Here, we identified Phyllopod (Phyl) as a key regulator that drives EE generation from ISCs. Phyl, which is normally suppressed by Notch, functions as an adaptor protein that bridges Tramtrack 69 (Ttk69) and E3 ubiquitin ligase Sina for degradation. Degradation of Ttk69 allows the activation of the Achaete-Scute Complex (AS-C)-Pros regulatory axis, which promotes EE specification. Interestingly, expression of AS-C genes in turn further induces Phyl expression, thereby establishing a positive feedback loop for continuous EE fate specification and commitment. This positive feedback circuit-driven regulatory mechanism could represent a common strategy for reliable and irreversible cell fate determination from progenitor cells. |
| 巻・号 | 10(1) |
| ページ | 43-57 |
| 公開日 | 2018-1-9 |
| DOI | 10.1016/j.stemcr.2017.11.014 |
| PII | S2213-6711(17)30521-0 |
| PMID | 29276156 |
| PMC | PMC5768918 |
| MeSH | Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster Enterocytes / cytology Enterocytes / metabolism Enteroendocrine Cells / cytology Enteroendocrine Cells / metabolism* Intestinal Mucosa / cytology Intestinal Mucosa / metabolism* Nuclear Proteins / genetics Nuclear Proteins / metabolism* Signal Transduction / physiology* Stem Cells / cytology Stem Cells / metabolism* |
| IF | 5.499 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |