論文 - 詳細
| RRC ID | 57147 |
|---|---|
| 著者 | Liao CP, Li H, Lee HH, Chien CT, Pan CL. |
| タイトル | Cell-Autonomous Regulation of Dendrite Self-Avoidance by the Wnt Secretory Factor MIG-14/Wntless. |
| ジャーナル | Neuron |
| Abstract |
Self-avoidance allows sister dendrites from the same neuron to form non-redundant coverage of the sensory territory and is important for neural circuitry functions. Here, we report an unexpected, cell-autonomous role of the Wnt-secretory factor MIG-14/Wntless in mediating dendrite self-avoidance in the C. elegans multidendritic PVD neurons. Similar findings in Drosophila suggest that this novel function of Wntless is conserved. The mig-14 mutant shows defects in dendrite self-avoidance, and ectopic MIG-14 expression triggers dendrite repulsion. Functions of dendrite self-avoidance and Wnt secretion could be mapped to distinct MIG-14 domains, indicating that these two functions of MIG-14 are genetically separable, consistent with lack of self-avoidance defects in the Wnt mutants. We further demonstrate that MIG-14 engages Wiskott-Aldrich syndrome protein (WASP)-dependent actin assembly to regulate dendrite self-avoidance. Our work expands the repertoire of self-avoidance molecules and uncovers a previously unknown, Wnt-independent function of MIG-14/Wntless. |
| 巻・号 | 98(2) |
| ページ | 320-334.e6 |
| 公開日 | 2018-4-18 |
| DOI | 10.1016/j.neuron.2018.03.031 |
| PII | S0896-6273(18)30237-X |
| PMID | 29673481 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans Caenorhabditis elegans Proteins / analysis Caenorhabditis elegans Proteins / biosynthesis* Carrier Proteins / analysis Carrier Proteins / biosynthesis* Cell Communication / physiology* Dendrites / chemistry Dendrites / physiology* Drosophila Proteins / analysis Drosophila Proteins / biosynthesis* Drosophila melanogaster HeLa Cells Humans Intracellular Signaling Peptides and Proteins / analysis Intracellular Signaling Peptides and Proteins / biosynthesis* Male Protein Transport / physiology Wnt Signaling Pathway / physiology |
| IF | 14.403 |
| 引用数 | 7 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 19 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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