論文 - 詳細
| RRC ID | 57167 |
|---|---|
| 著者 | Ng AYE, Peralta KRG, Pek JW. |
| タイトル | Germline Stem Cell Heterogeneity Supports Homeostasis in Drosophila. |
| ジャーナル | Stem Cell Reports |
| Abstract |
Adult and embryonic stem cells exhibit fluctuating gene expression; however, the biological significance of stem cell heterogeneity is not well understood. We show that, in Drosophila, female germline stem cells (GSCs) exhibit heterogeneous expression of a GSC differentiation-promoting factor Regena (Rga). The Drosophila homolog of human SON, dsn, is required to maintain GSC heterogeneity by suppressing sustained high levels of Rga. Reducing the expression of Rga in dsn mutants restores GSC heterogeneity and self-renewal. Thus, GSC heterogeneity is linked to GSC homeostasis. |
| 巻・号 | 11(1) |
| ページ | 13-21 |
| 公開日 | 2018-7-10 |
| DOI | 10.1016/j.stemcr.2018.05.005 |
| PII | S2213-6711(18)30222-4 |
| PMID | 29887366 |
| PMC | PMC6066994 |
| MeSH | Animals Biomarkers Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism Cell Differentiation Cell Self Renewal Drosophila / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism Female Gene Expression Regulation, Developmental Germ Cells / cytology* Germ Cells / metabolism* Homeostasis* Repressor Proteins / genetics Repressor Proteins / metabolism |
| IF | 5.499 |
| 引用数 | 2 |
| リソース情報 | |
| ショウジョウバエ | |