論文 - 詳細
| RRC ID | 57180 |
|---|---|
| 著者 | Widmer YF, Fritsch C, Jungo MM, Almeida S, Egger B, Sprecher SG. |
| タイトル | Multiple neurons encode CrebB dependent appetitive long-term memory in the mushroom body circuit. |
| ジャーナル | Elife |
| Abstract |
Lasting changes in gene expression are critical for the formation of long-term memories (LTMs), depending on the conserved CrebB transcriptional activator. While requirement of distinct neurons in defined circuits for different learning and memory phases have been studied in detail, only little is known regarding the gene regulatory changes that occur within these neurons. We here use the fruit fly as powerful model system to study the neural circuits of CrebB-dependent appetitive olfactory LTM. We edited the CrebB locus to create a GFP-tagged CrebB conditional knockout allele, allowing us to generate mutant, post-mitotic neurons with high spatial and temporal precision. Investigating CrebB-dependence within the mushroom body (MB) circuit we show that MB α/β and α'/β' neurons as well as MBON α3, but not in dopaminergic neurons require CrebB for LTM. Thus, transcriptional memory traces occur in different neurons within the same neural circuit. |
| 巻・号 | 7 |
| 公開日 | 2018-10-22 |
| DOI | 10.7554/eLife.39196 |
| PII | 39196 |
| PMID | 30346271 |
| PMC | PMC6234028 |
| MeSH | Alleles Animals Appetite / physiology* Cyclic AMP Response Element-Binding Protein / metabolism* Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* Gene Knockout Techniques Memory, Long-Term Mushroom Bodies / innervation* Mushroom Bodies / metabolism* Neurons / metabolism* Reproducibility of Results Trans-Activators / metabolism* |
| IF | 7.551 |
| 引用数 | 5 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 26 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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