RRC ID |
57187
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著者 |
Kubo A, Matsuka M, Minami R, Kimura F, Sakata-Niitsu R, Kokuryo A, Taniguchi K, Adachi-Yamada T, Nakagoshi H.
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タイトル |
Nutrient conditions sensed by the reproductive organ during development optimize male fecundity in Drosophila.
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ジャーナル |
Genes Cells
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Abstract |
Nutrient conditions affect the reproductive potential and lifespan of many organisms through the insulin signaling pathway. Although this is well characterized in female oogenesis, nutrient-dependent regulation of fertility/fecundity in males is not known. Seminal fluid components synthesized in the accessory gland are required for high fecundity in Drosophila males. The accessory gland is composed of two types of binucleated cells: a main cell and a secondary cell (SC). The transcription factors Defective proventriculus (Dve) and Abdominal-B (Abd-B) are strongly expressed in adult SCs, whose functions are essential for male fecundity. We found that gene expression of both Dve and Abd-B was down-regulated under nutrient-poor conditions. In addition, nutrient conditions during the pupal stage affected the size and number of SCs. These morphological changes clearly correlated with fecundity, suggesting that SCs act as nutrient sensors. Here, we provide evidence that Dve associates nutrient conditions with optimal reproductive potential in a target of rapamycin signaling-dependent manner.
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巻・号 |
23(7)
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ページ |
557-567
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公開日 |
2018-7-1
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DOI |
10.1111/gtc.12600
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PMID |
29846027
|
MeSH |
Animal Nutritional Physiological Phenomena
Animals
Drosophila / metabolism
Drosophila Proteins / metabolism
Drosophila Proteins / physiology*
Fertility / drug effects*
Gene Expression Regulation, Developmental / physiology
Genitalia / metabolism*
Genitalia / physiology
Homeodomain Proteins / genetics
Homeodomain Proteins / physiology*
Insulin / metabolism
Male
Semen / metabolism
Semen / physiology
Signal Transduction
Transcription Factors / metabolism
|
IF |
1.922
|
引用数 |
1
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リソース情報 |
ショウジョウバエ |
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