| RRC ID |
57193
|
| 著者 |
Zanini D, Giraldo D, Warren B, Katana R, Andrés M, Reddy S, Pauls S, Schwedhelm-Domeyer N, Geurten BRH, Göpfert MC.
|
| タイトル |
Proprioceptive Opsin Functions in Drosophila Larval Locomotion.
|
| ジャーナル |
Neuron
|
| Abstract |
Animals rely on mechanosensory feedback from proprioceptors to control locomotory body movements. Unexpectedly, we found that this movement control requires visual opsins. Disrupting the Drosophila opsins NINAE or Rh6 impaired larval locomotion and body contractions, independently of light and vision. Opsins were detected in chordotonal proprioceptors along the larval body, localizing to their ciliated dendrites. Loss of opsins impaired mechanically evoked proprioceptor spiking and cilium ultrastructure. Without NINAE or Rh6, NOMPC mechanotransduction channels leaked from proprioceptor cilia and ciliary Inactive (Iav) channels partly disappeared. Locomotion is shown to require opsins in proprioceptors, and the receptors are found to express the opsin gene Rh7, in addition to ninaE and Rh6. Besides implicating opsins in movement control, this documents roles of non-ciliary, rhabdomeric opsins in cilium organization, providing a model for a key transition in opsin evolution and suggesting that structural roles of rhabdomeric opsins preceded their use for light detection.
|
| 巻・号 |
98(1)
|
| ページ |
67-74.e4
|
| 公開日 |
2018-4-4
|
| DOI |
10.1016/j.neuron.2018.02.028
|
| PII |
S0896-6273(18)30149-1
|
| PMID |
29551493
|
| MeSH |
Animals
Animals, Genetically Modified
Drosophila Proteins / analysis
Drosophila Proteins / biosynthesis*
Drosophila melanogaster
Female
Larva / chemistry
Larva / metabolism*
Locomotion / physiology*
Male
Mechanotransduction, Cellular / physiology
Proprioception / physiology*
Rhodopsin / analysis
Rhodopsin / biosynthesis*
|
| IF |
14.403
|
| 引用数 |
11
|
| リソース情報 |
| ショウジョウバエ |
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