RRC ID 57201
著者 Prasad N, Hens K.
タイトル Sugar Promotes Feeding in Flies via the Serine Protease Homolog scarface.
ジャーナル Cell Rep
Abstract A balanced diet of macronutrients is critical for animal health. A lack of specific elements can have profound effects on behavior, reproduction, and lifespan. Here, we used Drosophila to understand how the brain responds to carbohydrate deprivation. We found that serine protease homologs (SPHs) are enriched among genes that are transcriptionally regulated in flies deprived of carbohydrates. Stimulation of neurons expressing one of these SPHs, Scarface (Scaf), or overexpression of scaf positively regulates feeding on nutritious sugars, whereas inhibition of these neurons or knockdown of scaf reduces feeding. This modulation of food intake occurs only in sated flies while hunger-induced feeding is unaffected. Furthermore, scaf expression correlates with the presence of sugar in the food. As Scaf and Scaf neurons promote feeding independent of the hunger state, and the levels of scaf are positively regulated by the presence of sugar, we conclude that scaf mediates the hedonic control of feeding.
巻・号 24(12)
ページ 3194-3206.e4
公開日 2018-9-18
DOI 10.1016/j.celrep.2018.08.059
PII S2211-1247(18)31346-9
PMID 30232002
PMC PMC6167639
MeSH Animals Brain / drug effects Brain / metabolism* Carbohydrate Metabolism* Dietary Carbohydrates / pharmacology Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster Feeding Behavior* Neurons / drug effects Neurons / metabolism Serine Proteases / genetics Serine Proteases / metabolism*
IF 7.815
引用数 3
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