RRC ID 57209
著者 Lu KL, Nelson JO, Watase GJ, Warsinger-Pepe N, Yamashita YM.
タイトル Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells.
ジャーナル Elife
Abstract rDNA loci, composed of hundreds of tandemly duplicated arrays of rRNA genes, are known to be among the most unstable genetic elements due to their repetitive nature. rDNA instability underlies aging (replicative senescence) in yeast cells, however, its contribution to the aging of multicellular organisms is poorly understood. In this study, we investigate the dynamics of rDNA loci during aging in the Drosophila male germline stem cell (GSC) lineage, and show that rDNA copy number decreases during aging. Our study further reveals that this age-dependent decrease in rDNA copy number is heritable from generation to generation, yet GSCs in young animals that inherited reduced rDNA copy number are capable of recovering normal rDNA copy number. Based on these findings, we propose that rDNA loci are dynamic genetic elements, where rDNA copy number changes dynamically yet is maintained through a recovery mechanism in the germline.
巻・号 7
公開日 2018-2-13
DOI 10.7554/eLife.32421
PII 32421
PMID 29436367
PMC PMC5811208
MeSH Aging* Animals DNA, Ribosomal / genetics* Drosophila / genetics* Drosophila / physiology Gene Dosage* Genetic Variation* Genomic Instability Germ Cells Male Stem Cells
IF 7.551
引用数 15
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