RRC ID 57218
Author Brock AR, Seto M, Smith-Bolton RK.
Title Cap-n-Collar Promotes Tissue Regeneration by Regulating ROS and JNK Signaling in the Drosophila melanogaster Wing Imaginal Disc.
Journal Genetics
Abstract Nrf2 ortholog, which is required for regeneration. Cnc regulates reactive oxygen species levels in the regenerating epithelium, and affects c-Jun N-terminal protein kinase (JNK) signaling, growth, debris localization, and pupariation timing. Here, we present the results of our screen and propose a model wherein Cnc regulates regeneration by maintaining an optimal level of reactive oxygen species to promote JNK signaling.
Volume 206(3)
Pages 1505-1520
Published 2017-7
DOI 10.1534/genetics.116.196832
PII genetics.116.196832
PMID 28512185
PMC PMC5500147
MeSH Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism Imaginal Discs / metabolism* Imaginal Discs / physiology MAP Kinase Kinase 4 / metabolism MAP Kinase Signaling System Reactive Oxygen Species / metabolism* Regeneration* Repressor Proteins / genetics Repressor Proteins / metabolism* Wings, Animal / growth & development Wings, Animal / metabolism
IF 4.075