Reference - Detail
| RRC ID | 57228 |
|---|---|
| Author | Hao Y, Jin LH. |
| Title | Dual role for Jumu in the control of hematopoietic progenitors in the Drosophila lymph gland. |
| Journal | Elife |
| Abstract |
The Drosophila lymph gland is a hematopoietic organ in which the maintenance of hematopoietic progenitor cell fate relies on intrinsic factors and extensive interaction with cells within a microenvironment. The posterior signaling center (PSC) is required for maintaining the balance between progenitors and their differentiation into mature hemocytes. Moreover, some factors from the progenitors cell-autonomously control blood cell differentiation. Here, we show that Jumeau (Jumu), a member of the forkhead (Fkh) transcription factor family, controls hemocyte differentiation of lymph gland through multiple regulatory mechanisms. Jumu maintains the proper differentiation of prohemocytes by cell-autonomously regulating the expression of Col in medullary zone and by non-cell-autonomously preventing the generation of expanded PSC cells. Jumu can also cell-autonomously control the proliferation of PSC cells through positive regulation of dMyc expression. We also show that a deficiency of jumu throughout the lymph gland can induce the differentiation of lamellocytes via activating Toll signaling. |
| Volume | 6 |
| Published | 2017-3-28 |
| DOI | 10.7554/eLife.25094 |
| PII | e25094 |
| PMID | 28350299 |
| PMC | PMC5391210 |
| MeSH | Animals Cell Differentiation Cell Proliferation Drosophila Proteins / metabolism* Drosophila melanogaster / physiology* Hematopoietic Stem Cells / physiology* Hemocytes / physiology* Lymph Nodes / cytology* Transcription Factors / metabolism* |
| IF | 7.551 |
| Times Cited | 10 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | |