RRC ID 57233
著者 Sung HY, Jeong YT, Lim JY, Kim H, Oh SM, Hwang SW, Kwon JY, Moon SJ.
タイトル Heterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds.
ジャーナル Nat Commun
Abstract Animals must detect aversive compounds to survive. Bitter taste neurons express heterogeneous combinations of bitter receptors that diversify their response profiles, but this remains poorly understood. Here we describe groups of taste neurons in Drosophila that detect the same bitter compounds using unique combinations of gustatory receptors (GRs). These distinct complexes also confer responsiveness to non-overlapping sets of additional compounds. While either GR32a/GR59c/GR66a or GR22e/GR32a/GR66a heteromultimers are sufficient for lobeline, berberine, and denatonium detection, only GR22e/GR32a/GR66a responds to strychnine. Thus, despite minimal sequence-similarity, Gr22e and Gr59c show considerable but incomplete functional overlap. Since the gain- or loss-of-function of Gr22e or Gr59c alters bitter taste response profiles, we conclude a taste neuron's specific combination of Grs determines its response profile. We suspect the heterogeneity of Gr expression in Drosophila taste neurons diversifies bitter compound detection, improving animal fitness under changing environmental conditions that present a variety of aversive compounds.
巻・号 8(1)
ページ 1484
公開日 2017-11-14
DOI 10.1038/s41467-017-01639-5
PII 10.1038/s41467-017-01639-5
PMID 29133786
PMC PMC5684318
MeSH Animals Animals, Genetically Modified Aversive Agents / pharmacology* Drosophila Proteins / genetics Drosophila Proteins / physiology* Drosophila melanogaster / physiology* Environmental Exposure Gain of Function Mutation / physiology Loss of Function Mutation / physiology Neurons / drug effects Neurons / physiology* Receptors, Cell Surface / genetics Receptors, Cell Surface / physiology* Taste / drug effects Taste / physiology*
IF 11.878
引用数 16
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