RRC ID |
57233
|
著者 |
Sung HY, Jeong YT, Lim JY, Kim H, Oh SM, Hwang SW, Kwon JY, Moon SJ.
|
タイトル |
Heterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds.
|
ジャーナル |
Nat Commun
|
Abstract |
Animals must detect aversive compounds to survive. Bitter taste neurons express heterogeneous combinations of bitter receptors that diversify their response profiles, but this remains poorly understood. Here we describe groups of taste neurons in Drosophila that detect the same bitter compounds using unique combinations of gustatory receptors (GRs). These distinct complexes also confer responsiveness to non-overlapping sets of additional compounds. While either GR32a/GR59c/GR66a or GR22e/GR32a/GR66a heteromultimers are sufficient for lobeline, berberine, and denatonium detection, only GR22e/GR32a/GR66a responds to strychnine. Thus, despite minimal sequence-similarity, Gr22e and Gr59c show considerable but incomplete functional overlap. Since the gain- or loss-of-function of Gr22e or Gr59c alters bitter taste response profiles, we conclude a taste neuron's specific combination of Grs determines its response profile. We suspect the heterogeneity of Gr expression in Drosophila taste neurons diversifies bitter compound detection, improving animal fitness under changing environmental conditions that present a variety of aversive compounds.
|
巻・号 |
8(1)
|
ページ |
1484
|
公開日 |
2017-11-14
|
DOI |
10.1038/s41467-017-01639-5
|
PII |
10.1038/s41467-017-01639-5
|
PMID |
29133786
|
PMC |
PMC5684318
|
MeSH |
Animals
Animals, Genetically Modified
Aversive Agents / pharmacology*
Drosophila Proteins / genetics
Drosophila Proteins / physiology*
Drosophila melanogaster / physiology*
Environmental Exposure
Gain of Function Mutation / physiology
Loss of Function Mutation / physiology
Neurons / drug effects
Neurons / physiology*
Receptors, Cell Surface / genetics
Receptors, Cell Surface / physiology*
Taste / drug effects
Taste / physiology*
|
IF |
11.878
|
引用数 |
16
|
リソース情報 |
ショウジョウバエ |
|