論文 - 詳細
| RRC ID | 57240 |
|---|---|
| 著者 | Bahrampour S, Gunnar E, Jonsson C, Ekman H, Thor S. |
| タイトル | Neural Lineage Progression Controlled by a Temporal Proliferation Program. |
| ジャーナル | Dev Cell |
| Abstract |
Great progress has been made in identifying transcriptional programs that establish stem cell identity. In contrast, we have limited insight into how these programs are down-graded in a timely manner to halt proliferation and allow for cellular differentiation. Drosophila embryonic neuroblasts undergo such a temporal progression, initially dividing to bud off daughters that divide once (type I), then switching to generating non-dividing daughters (type 0), and finally exiting the cell cycle. We identify six early transcription factors that drive neuroblast and type I daughter proliferation. Early factors are gradually replaced by three late factors, acting to trigger the type I→0 daughter proliferation switch and eventually to stop neuroblasts. Early and late factors regulate each other and four key cell-cycle genes, providing a logical genetic pathway for these transitions. The identification of this extensive driver-stopper temporal program controlling neuroblast lineage progression may have implications for studies in many other systems. |
| 巻・号 | 43(3) |
| ページ | 332-348.e4 |
| 公開日 | 2017-11-6 |
| DOI | 10.1016/j.devcel.2017.10.004 |
| PII | S1534-5807(17)30817-1 |
| PMID | 29112852 |
| MeSH | Animals Cell Cycle / physiology* Cell Differentiation / physiology Cell Lineage* / physiology Cell Proliferation / physiology* Drosophila Proteins / metabolism Drosophila melanogaster / cytology* Drosophila melanogaster / metabolism Gene Expression Regulation, Developmental / physiology* Neural Stem Cells / cytology* Neural Stem Cells / metabolism Neurons / metabolism Nuclear Proteins / metabolism Transcription Factors / metabolism |
| IF | 9.19 |
| 引用数 | 15 |
| オルトメトリクス指標 |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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