論文 - 詳細
| RRC ID | 57266 |
|---|---|
| 著者 | Ortega JM, Genç Ö, Davis GW. |
| タイトル | Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity. |
| ジャーナル | Elife |
| Abstract |
Presynaptic homeostatic plasticity (PHP) compensates for impaired postsynaptic neurotransmitter receptor function through a rapid, persistent adjustment of neurotransmitter release, an effect that can exceed 200%. An unexplained property of PHP is the preservation of short-term plasticity (STP), thereby stabilizing activity-dependent synaptic information transfer. We demonstrate that the dramatic potentiation of presynaptic release during PHP is achieved while simultaneously maintaining a constant ratio of primed to super-primed synaptic vesicles, thereby preserving STP. Mechanistically, genetic, biochemical and electrophysiological evidence argue that a constant ratio of primed to super-primed synaptic vesicles is achieved by the concerted action of three proteins: Unc18, Syntaxin1A and RIM. Our data support a model based on the regulated availability of Unc18 at the presynaptic active zone, a process that is restrained by Syntaxin1A and facilitated by RIM. As such, regulated vesicle priming/super-priming enables PHP to stabilize both synaptic gain and the activity-dependent transfer of information at a synapse. |
| 巻・号 | 7 |
| 公開日 | 2018-11-13 |
| DOI | 10.7554/eLife.40385 |
| PII | 40385 |
| PMID | 30422113 |
| PMC | PMC6250423 |
| MeSH | Animals Drosophila Proteins / metabolism Drosophila melanogaster Nerve Tissue Proteins / metabolism Neuronal Plasticity* Neurotransmitter Agents / metabolism* Presynaptic Terminals / metabolism* Synaptic Vesicles / metabolism Syntaxin 1 / metabolism rab3 GTP-Binding Proteins / metabolism |
| IF | 7.551 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |