RRC ID 57266
著者 Ortega JM, Genç Ö, Davis GW.
タイトル Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity.
ジャーナル Elife
Abstract Presynaptic homeostatic plasticity (PHP) compensates for impaired postsynaptic neurotransmitter receptor function through a rapid, persistent adjustment of neurotransmitter release, an effect that can exceed 200%. An unexplained property of PHP is the preservation of short-term plasticity (STP), thereby stabilizing activity-dependent synaptic information transfer. We demonstrate that the dramatic potentiation of presynaptic release during PHP is achieved while simultaneously maintaining a constant ratio of primed to super-primed synaptic vesicles, thereby preserving STP. Mechanistically, genetic, biochemical and electrophysiological evidence argue that a constant ratio of primed to super-primed synaptic vesicles is achieved by the concerted action of three proteins: Unc18, Syntaxin1A and RIM. Our data support a model based on the regulated availability of Unc18 at the presynaptic active zone, a process that is restrained by Syntaxin1A and facilitated by RIM. As such, regulated vesicle priming/super-priming enables PHP to stabilize both synaptic gain and the activity-dependent transfer of information at a synapse.
巻・号 7
公開日 2018-11-13
DOI 10.7554/eLife.40385
PII 40385
PMID 30422113
PMC PMC6250423
MeSH Animals Drosophila Proteins / metabolism Drosophila melanogaster Nerve Tissue Proteins / metabolism Neuronal Plasticity* Neurotransmitter Agents / metabolism* Presynaptic Terminals / metabolism* Synaptic Vesicles / metabolism Syntaxin 1 / metabolism rab3 GTP-Binding Proteins / metabolism
IF 7.551
引用数 6
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