RRC ID 57286
著者 Hoyer N, Zielke P, Hu C, Petersen M, Sauter K, Scharrenberg R, Peng Y, Kim CC, Han C, Parrish JZ, Soba P.
タイトル Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons.
ジャーナル Cell Rep
Abstract Dendrite morphogenesis is a highly regulated process that gives rise to stereotyped receptive fields, which are required for proper neuronal connectivity and function. Specific classes of neurons, including Drosophila class IV dendritic arborization (C4da) neurons, also feature complete space-filling growth of dendrites. In this system, we have identified the substrate-derived TGF-β ligand maverick (mav) as a developmental signal promoting space-filling growth through the neuronal Ret receptor. Both are necessary for radial spreading of C4da neuron dendrites, and Ret is required for neuronal uptake of Mav. Moreover, local changes in Mav levels result in directed dendritic growth toward regions with higher ligand availability. Our results suggest that Mav acts as a substrate-derived secreted signal promoting dendrite growth within not-yet-covered areas of the receptive field to ensure space-filling dendritic growth.
巻・号 24(9)
ページ 2261-2272.e5
公開日 2018-8-28
DOI 10.1016/j.celrep.2018.07.092
PII S2211-1247(18)31225-7
PMID 30157422
PMC PMC6191840
MeSH Animals Dendrites Drosophila Proteins / metabolism* Drosophila melanogaster Proto-Oncogene Proteins c-ret / metabolism* Sensory Receptor Cells / cytology* Sensory Receptor Cells / metabolism* Transforming Growth Factor beta / metabolism*
IF 7.815
引用数 2
リソース情報
ショウジョウバエ DGRC#103497