| RRC ID |
57320
|
| 著者 |
Manocha GD, Floden AM, Miller NM, Smith AJ, Nagamoto-Combs K, Saito T, Saido TC, Combs CK.
|
| タイトル |
Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice.
|
| ジャーナル |
Neurobiol Aging
|
| Abstract |
The amyloid beta (Aβ) peptide is associated with the neurodegenerative and inflammatory changes in brains affected by Alzheimer's disease (AD). We hypothesized that the enteric nervous system also produces Aβ in an intestinal component of disease. To test this idea, we compared C57BL/6 wild-type (WT) male and female mice to two models of Alzheimer's disease, amyloid precursor protein (APP)/presenilin 1 (PS1) mice and amyloid precursor protein NL-G-F (AppNL-G-F) mice, at 3, 6, and 12 months of age. Brain Aβ plaque deposition in AppNL-G-F mice preceded that in the APP/PS1 mice, observable by 3 months. Three-month-old female AppNL-G-F mice had decreased intestinal motility compared with WT and APP/PS1 mice. However, 3-month-old female APP/PS1 mice demonstrated increased intestinal permeability compared with WT and AppNL-G-F mice. Both sexes of APP/PS1 and AppNL-G-F mice demonstrated increased colon lipocalin 2 mRNA and insoluble Aβ 1-42 levels at 3 months. These data demonstrate an unrecognized enteric aspect of disease in 2 different mouse models correlating with the earliest brain changes.
|
| 巻・号 |
81
|
| ページ |
166-176
|
| 公開日 |
2019-9-1
|
| DOI |
10.1016/j.neurobiolaging.2019.05.025
|
| PII |
S0197-4580(19)30181-2
|
| PMID |
31284126
|
| PMC |
PMC6732235
|
| MeSH |
Alzheimer Disease / etiology*
Amyloid beta-Peptides / metabolism*
Amyloid beta-Protein Precursor
Animals
Cytokines / metabolism
Disease Models, Animal
Disease Progression
Female
Gastrointestinal Motility
Intestinal Mucosa / metabolism*
Intestines / innervation
Lipocalin-2 / metabolism
Male
Mice, Inbred C57BL
Mice, Transgenic
Presenilin-1
Temporal Lobe / metabolism*
|
| IF |
4.398
|
| 引用数 |
3
|
| リソース情報 |
| 実験動物マウス |
RBRC06334 |
