論文 - 詳細
| RRC ID | 57336 |
|---|---|
| 著者 | Yan Y, Wang H, Hu M, Jiang L, Wang Y, Liu P, Liang X, Liu J, Li C, Lindström-Battle A, Lam SM, Shui G, Deng WM, Jiao R. |
| タイトル | HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. |
| ジャーナル | Dev Cell |
| Abstract |
Age-dependent ectopic fat accumulation (EFA) in animals contributes to the progression of tissue aging and diseases such as obesity, diabetes, and cancer. However, the primary causes of age-dependent EFA remain largely elusive. Here, we characterize the occurrence of age-dependent EFA in Drosophila and identify HDAC6, a cytosolic histone deacetylase, as a suppressor of EFA. Loss of HDAC6 leads to significant age-dependent EFA, lipid composition imbalance, and reduced animal longevity on a high-fat diet. The EFA and longevity phenotypes are ameliorated by a reduction of the lipid-droplet-resident protein PLIN2. We show that HDAC6 is associated physically with the chaperone protein dHsc4/Hsc70 to maintain the proteostasis of PLIN2. These findings indicate that proteostasis collapse serves as an intrinsic cue to cause age-dependent EFA. Our study suggests that manipulation of proteostasis could be an alternative approach to the treatment of age-related metabolic diseases such as obesity and diabetes. |
| 巻・号 | 43(1) |
| ページ | 99-111.e5 |
| 公開日 | 2017-10-9 |
| DOI | 10.1016/j.devcel.2017.09.001 |
| PII | S1534-5807(17)30714-1 |
| PMID | 28966044 |
| MeSH | Aging Animals Autophagy / physiology Cytosol / metabolism Diet, High-Fat Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism* Fats / metabolism* Histone Deacetylase 6 Histone Deacetylases / metabolism* Lipid Droplets / metabolism* Longevity / physiology Perilipin-2 / metabolism* |
| IF | 9.19 |
| 引用数 | 10 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#105013 |