Reference - Detail
| RRC ID | 57347 |
|---|---|
| Author | Otsuki L, Brand AH. |
| Title | Dorsal-Ventral Differences in Neural Stem Cell Quiescence Are Induced by p57KIP2/Dacapo. |
| Journal | Dev Cell |
| Abstract |
Quiescent neural stem cells (NSCs) in the adult brain are regenerative cells that could be activated therapeutically to repair damage. It is becoming apparent that quiescent NSCs exhibit heterogeneity in their propensity for activation and in the progeny that they generate. We discovered recently that NSCs undergo quiescence in either G0 or G2 in the Drosophila brain, challenging the notion that all quiescent stem cells are G0 arrested. We found that G2-quiescent NSCs become activated prior to G0 NSCs. Here, we show that the cyclin-dependent kinase inhibitor Dacapo (Dap; ortholog of p57KIP2) determines whether NSCs enter G0 or G2 quiescence during embryogenesis. We demonstrate that the dorsal patterning factor, Muscle segment homeobox (Msh; ortholog of MSX1/2/3) binds directly to the Dap locus and induces Dap expression in dorsal NSCs, resulting in G0 arrest, while more ventral NSCs undergo G2 quiescence. Our results reveal region-specific regulation of stem cell quiescence. |
| Volume | 49(2) |
| Pages | 293-300.e3 |
| Published | 2019-4-22 |
| DOI | 10.1016/j.devcel.2019.02.015 |
| PII | S1534-5807(19)30138-8 |
| PMID | 30905769 |
| PMC | PMC6486397 |
| MeSH | Adult Stem Cells / cytology Adult Stem Cells / metabolism Animals Cell Cycle / physiology Cell Division / physiology Cyclin-Dependent Kinase Inhibitor p57 / metabolism* Drosophila Proteins / metabolism* Drosophila melanogaster / cytology Drosophila melanogaster / metabolism G2 Phase / physiology Homeodomain Proteins / metabolism Neural Stem Cells / cytology Neural Stem Cells / metabolism* Neurogenesis / physiology Nuclear Proteins / metabolism* Resting Phase, Cell Cycle / physiology |
| IF | 9.19 |
| Times Cited | 5 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 56 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#116970 DGRC#116971 |