RRC ID 57367
著者 Zhang X, Coates K, Dacks A, Günay C, Lauritzen JS, Li F, Calle-Schuler SA, Bock D, Gaudry Q.
タイトル Local synaptic inputs support opposing, network-specific odor representations in a widely projecting modulatory neuron.
ジャーナル Elife
Abstract Serotonin plays different roles across networks within the same sensory modality. Previously, we used whole-cell electrophysiology in Drosophila to show that serotonergic neurons innervating the first olfactory relay are inhibited by odorants (Zhang and Gaudry, 2016). Here we show that network-spanning serotonergic neurons segregate information about stimulus features, odor intensity and identity, by using opposing coding schemes in different olfactory neuropil. A pair of serotonergic neurons (the CSDns) innervate the antennal lobe and lateral horn, which are first and second order neuropils. CSDn processes in the antennal lobe are inhibited by odors in an identity independent manner. In the lateral horn, CSDn processes are excited in an odor identity dependent manner. Using functional imaging, modeling, and EM reconstruction, we demonstrate that antennal lobe derived inhibition arises from local GABAergic inputs and acts as a means of gain control on branch-specific inputs that the CSDns receive within the lateral horn.
巻・号 8
公開日 2019-7-2
DOI 10.7554/eLife.46839
PII 46839
PMID 31264962
PMC PMC6660217
MeSH Animals Arthropod Antennae / pathology Brain / physiology Drosophila melanogaster / physiology Female Green Fluorescent Proteins / metabolism Odorants* Olfactory Receptor Neurons / metabolism* Serotonergic Neurons / physiology Synapses / metabolism*
IF 7.551
引用数 1
リソース情報
ショウジョウバエ DGRC#104134