| RRC ID |
57369
|
| 著者 |
Tokusumi Y, Tokusumi T, Schulz RA.
|
| タイトル |
Mechanical stress to Drosophila larvae stimulates a cellular immune response through the JAK/STAT signaling pathway.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
Acute inflammation can cause serious tissue damage and disease in physiologically-challenged organisms. The precise mechanisms leading to these detrimental effects remain to be determined. In this study, we utilize a reproducible means to induce cellular immune activity in Drosophila larvae in response to mechanical stress. That is, forceps squeeze-administered stress induces lamellocytes, a defensive hemocyte type that normally appears in response to wasp infestation of larvae. The posterior signaling center (PSC) is a cellular microenvironment in the larval hematopoietic lymph gland that is vital for lamellocyte induction upon parasitoid attack. However, we found the PSC was not required for mechanical stress-induced lamellocyte production. In addition, we observed that mechanical injury caused a systemic expression of Unpaired3. This cytokine is both necessary and sufficient to activate the cellular immune response to the imposed stress. These findings provide new insights into the communication between injured tissues and immune system induction, using stress-challenged Drosophila larvae as a tractable model system.
|
| 巻・号 |
502(3)
|
| ページ |
415-421
|
| 公開日 |
2018-7-20
|
| DOI |
10.1016/j.bbrc.2018.05.192
|
| PII |
S0006-291X(18)31281-6
|
| PMID |
29856996
|
| MeSH |
Animals
Animals, Genetically Modified
Cellular Microenvironment
Drosophila Proteins / metabolism
Drosophila melanogaster / immunology*
Drosophila melanogaster / metabolism*
Drosophila melanogaster / parasitology
Hemocytes / cytology
Hemocytes / immunology
Immunity, Cellular
Janus Kinases / metabolism
Larva / immunology
Larva / metabolism
Larva / parasitology
STAT Transcription Factors / metabolism
Signal Transduction
Stress, Mechanical
Transcription Factors / metabolism
Wasps / immunology
Wasps / pathogenicity
|
| IF |
2.705
|
| 引用数 |
5
|
| リソース情報 |
| ショウジョウバエ |
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