論文 - 詳細
| RRC ID | 57372 |
|---|---|
| 著者 | Jagannathan M, Cummings R, Yamashita YM. |
| タイトル | A conserved function for pericentromeric satellite DNA. |
| ジャーナル | Elife |
| Abstract |
A universal and unquestioned characteristic of eukaryotic cells is that the genome is divided into multiple chromosomes and encapsulated in a single nucleus. However, the underlying mechanism to ensure such a configuration is unknown. Here, we provide evidence that pericentromeric satellite DNA, which is often regarded as junk, is a critical constituent of the chromosome, allowing the packaging of all chromosomes into a single nucleus. We show that the multi-AT-hook satellite DNA-binding proteins, Drosophila melanogaster D1 and mouse HMGA1, play an evolutionarily conserved role in bundling pericentromeric satellite DNA from heterologous chromosomes into 'chromocenters', a cytological association of pericentromeric heterochromatin. Defective chromocenter formation leads to micronuclei formation due to budding from the interphase nucleus, DNA damage and cell death. We propose that chromocenter and satellite DNA serve a fundamental role in encapsulating the full complement of the genome within a single nucleus, the universal characteristic of eukaryotic cells. |
| 巻・号 | 7 |
| 公開日 | 2018-3-26 |
| DOI | 10.7554/eLife.34122 |
| PII | 34122 |
| PMID | 29578410 |
| PMC | PMC5957525 |
| MeSH | Animals Cell Nucleus / metabolism* Chromosomes / metabolism* DNA, Satellite / metabolism* DNA-Binding Proteins / metabolism Drosophila Proteins / metabolism Drosophila melanogaster Eukaryotic Cells / physiology* HMGA1a Protein / metabolism Mice |
| IF | 7.551 |
| 引用数 | 16 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 55 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#110806 DGRC#140754 |