論文 - 詳細
| RRC ID | 57380 |
|---|---|
| 著者 | Kim HS, Lee MB, Lee D, Min KY, Koo J, Kim HW, Park YH, Kim SJ, Ikutani M, Takaki S, Kim YM, Choi WS. |
| タイトル | The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity. |
| ジャーナル | Sci Adv |
| Abstract |
The function of regulatory immune cells in peripheral tissues is crucial to the onset and severity of various diseases. Interleukin-10 (IL-10)-producing regulatory B (IL-10+ Breg) cells are known to suppress various inflammatory diseases. However, evidence for the mechanism by which IL-10+ Breg cells are generated and maintained is still very limited. Here, we found that IL-10+ Breg cells suppress the activation of IL-13-producing type 2 innate lymphoid cells (IL-13+ ILC2s) in an IL-10-dependent manner in mice with oxazolone-induced severe contact hypersensitivity (CHS). Mast cell (MC) IL-5 was important for maintaining the population of IL-10+ Breg cells in peripheral lymphoid tissues. Overall, these results uncover a previously unknown mechanism of MCs as a type of immunoregulatory cell and elucidate the cross-talk among MCs, IL-10+ Breg cells, and IL-13+ ILC2s in CHS. |
| 巻・号 | 5(7) |
| ページ | eaav8152 |
| 公開日 | 2019-7-1 |
| DOI | 10.1126/sciadv.aav8152 |
| PII | aav8152 |
| PMID | 31328158 |
| PMC | PMC6636983 |
| MeSH | Animals B-Lymphocyte Subsets / immunology B-Lymphocyte Subsets / metabolism B-Lymphocytes, Regulatory / immunology* B-Lymphocytes, Regulatory / metabolism* Cytokines / metabolism Dermatitis, Contact / etiology* Dermatitis, Contact / metabolism* Dermatitis, Contact / pathology Disease Models, Animal Fluorescent Antibody Technique Immunoglobulin Isotypes / immunology Interleukin-5 / metabolism* Male Mast Cells / immunology* Mast Cells / metabolism* Mice Mice, Knockout Oxazolone / adverse effects* Peripheral Tolerance* |
| IF | 12.804 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00995 |