RRC ID 57380
著者 Kim HS, Lee MB, Lee D, Min KY, Koo J, Kim HW, Park YH, Kim SJ, Ikutani M, Takaki S, Kim YM, Choi WS.
タイトル The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity.
ジャーナル Sci Adv
Abstract The function of regulatory immune cells in peripheral tissues is crucial to the onset and severity of various diseases. Interleukin-10 (IL-10)-producing regulatory B (IL-10+ Breg) cells are known to suppress various inflammatory diseases. However, evidence for the mechanism by which IL-10+ Breg cells are generated and maintained is still very limited. Here, we found that IL-10+ Breg cells suppress the activation of IL-13-producing type 2 innate lymphoid cells (IL-13+ ILC2s) in an IL-10-dependent manner in mice with oxazolone-induced severe contact hypersensitivity (CHS). Mast cell (MC) IL-5 was important for maintaining the population of IL-10+ Breg cells in peripheral lymphoid tissues. Overall, these results uncover a previously unknown mechanism of MCs as a type of immunoregulatory cell and elucidate the cross-talk among MCs, IL-10+ Breg cells, and IL-13+ ILC2s in CHS.
巻・号 5(7)
ページ eaav8152
公開日 2019-7-1
DOI 10.1126/sciadv.aav8152
PII aav8152
PMID 31328158
PMC PMC6636983
MeSH Animals B-Lymphocyte Subsets / immunology B-Lymphocyte Subsets / metabolism B-Lymphocytes, Regulatory / immunology* B-Lymphocytes, Regulatory / metabolism* Cytokines / metabolism Dermatitis, Contact / etiology* Dermatitis, Contact / metabolism* Dermatitis, Contact / pathology Disease Models, Animal Fluorescent Antibody Technique Immunoglobulin Isotypes / immunology Interleukin-5 / metabolism* Male Mast Cells / immunology* Mast Cells / metabolism* Mice Mice, Knockout Oxazolone / adverse effects* Peripheral Tolerance*
IF 12.804
引用数 1
リソース情報
実験動物マウス RBRC00995