論文 - 詳細
| RRC ID | 57465 |
|---|---|
| 著者 | Ghosh N, Bakshi A, Khandelwal R, Rajan SG, Joshi R. |
| タイトル | The Hox gene Abdominal-B uses DoublesexF as a cofactor to promote neuroblast apoptosis in the Drosophila central nervous system. |
| ジャーナル | Development |
| Abstract |
Highly conserved DM domain-containing transcription factors (Doublesex/MAB-3/DMRT1) are responsible for generating sexually dimorphic features. In the Drosophila central nervous system, a set of Doublesex (Dsx)-expressing neuroblasts undergo apoptosis in females whereas their male counterparts proliferate and give rise to serotonergic neurons crucial for adult mating behaviour. Our study demonstrates that the female-specific isoform of Dsx collaborates with Hox gene Abdominal-B (Abd-B) to bring about this apoptosis. Biochemical results suggest that proteins AbdB and Dsx interact through their highly conserved homeodomain and DM domain, respectively. This interaction is translated into a cooperative binding of the two proteins on the apoptotic enhancer in the case of females but not in the case of males, resulting in female-specific activation of apoptotic genes. The capacity of AbdB to use the sex-specific isoform of Dsx as a cofactor underlines the possibility that these two classes of protein are capable of cooperating in selection and regulation of target genes in a tissue- and sex-specific manner. We propose that this interaction could be a common theme in generating sexual dimorphism in different tissues across different species. |
| 巻・号 | 146(16) |
| 公開日 | 2019-8-22 |
| DOI | 10.1242/dev.175158 |
| PII | dev.175158 |
| PMID | 31371379 |
| PMC | PMC6737903 |
| MeSH | Animals Apoptosis* / genetics DNA-Binding Proteins / genetics DNA-Binding Proteins / physiology* Drosophila / cytology* Drosophila / embryology Drosophila / genetics* Drosophila Proteins / genetics Drosophila Proteins / physiology* Female Gene Expression Regulation, Developmental Genes, Homeobox* Homeodomain Proteins / genetics Homeodomain Proteins / physiology* Male Neural Stem Cells / cytology* Protein Isoforms / genetics Protein Isoforms / physiology Sex Characteristics |
| IF | 5.763 |
| 引用数 | 0 |
| リソース情報 | |
| ショウジョウバエ | 17117R-4 17117R-2 |