RRC ID 57541
Author Stolper J, Ambrosio EM, Danciu DP, Buono L, Elliott DA, Naruse K, Martínez-Morales JR, Marciniak-Czochra A, Centanin L.
Title Stem cell topography splits growth and homeostatic functions in the fish gill.
Journal Elife
Abstract While lower vertebrates contain adult stem cells (aSCs) that maintain homeostasis and drive un-exhaustive organismal growth, mammalian aSCs display mainly the homeostatic function. Here, we use lineage analysis in the medaka fish gill to address aSCs and report separate stem cell populations for homeostasis and growth. These aSCs are fate-restricted during the entire post-embryonic life and even during re-generation paradigms. We use chimeric animals to demonstrate that p53 mediates growth coordination among fate-restricted aSCs, suggesting a hierarchical organisation among lineages in composite organs like the fish gill. Homeostatic and growth aSCs are clonal but differ in their topology; modifications in tissue architecture can convert the homeostatic zone into a growth zone, indicating a leading role for the physical niche defining stem cell output. We hypothesise that physical niches are main players to restrict aSCs to a homeostatic function in animals with fixed adult size.
Volume 8
Published 2019-5-16
DOI 10.7554/eLife.43747
PII 43747
PMID 31090541
PMC PMC6534379
MeSH Adipose Tissue / growth & development* Adipose Tissue / metabolism Adult Stem Cells / metabolism* Animals Cell Differentiation / genetics Chimera / genetics Chimera / growth & development Genes, p53 / genetics Gills / growth & development* Gills / metabolism Homeostasis / genetics Humans Oryzias / growth & development* Oryzias / metabolism Stem Cell Niche / genetics
IF 7.551
Times Cited 0
Medaka OK-Cab (MT830) p53(E241x) (MT894) GaudiHspCre.A (TG1053) GaudiUbiq.iCre (TG1054) GaudiRSG (TG1055) GaudiLxBBW (TG1057)