| RRC ID |
57541
|
| 著者 |
Stolper J, Ambrosio EM, Danciu DP, Buono L, Elliott DA, Naruse K, Martínez-Morales JR, Marciniak-Czochra A, Centanin L.
|
| タイトル |
Stem cell topography splits growth and homeostatic functions in the fish gill.
|
| ジャーナル |
Elife
|
| Abstract |
While lower vertebrates contain adult stem cells (aSCs) that maintain homeostasis and drive un-exhaustive organismal growth, mammalian aSCs display mainly the homeostatic function. Here, we use lineage analysis in the medaka fish gill to address aSCs and report separate stem cell populations for homeostasis and growth. These aSCs are fate-restricted during the entire post-embryonic life and even during re-generation paradigms. We use chimeric animals to demonstrate that p53 mediates growth coordination among fate-restricted aSCs, suggesting a hierarchical organisation among lineages in composite organs like the fish gill. Homeostatic and growth aSCs are clonal but differ in their topology; modifications in tissue architecture can convert the homeostatic zone into a growth zone, indicating a leading role for the physical niche defining stem cell output. We hypothesise that physical niches are main players to restrict aSCs to a homeostatic function in animals with fixed adult size.
|
| 巻・号 |
8
|
| 公開日 |
2019-5-16
|
| DOI |
10.7554/eLife.43747
|
| PII |
43747
|
| PMID |
31090541
|
| PMC |
PMC6534379
|
| MeSH |
Adipose Tissue / growth & development*
Adipose Tissue / metabolism
Adult Stem Cells / metabolism*
Animals
Cell Differentiation / genetics
Chimera / genetics
Chimera / growth & development
Genes, p53 / genetics
Gills / growth & development*
Gills / metabolism
Homeostasis / genetics
Humans
Oryzias / growth & development*
Oryzias / metabolism
Stem Cell Niche / genetics
|
| IF |
7.551
|
| 引用数 |
0
|
| リソース情報 |
| メダカ |
OK-Cab (MT830)
p53(E241x) (MT894)
GaudiHspCre.A (TG1053)
GaudiUbiq.iCre (TG1054)
GaudiRSG (TG1055)
GaudiLxBBW (TG1057) |
