論文 - 詳細
| RRC ID | 57558 |
|---|---|
| 著者 | Wu J, Kung J, Dong J, Chang L, Xie C, Habib A, Hawes S, Yang N, Chen V, Liu Z, Evans R, Liang B, Sun L, Ding J, Yu J, Saez-Atienzar S, Tang B, Khaliq Z, Lin DT, Le W, Cai H. |
| タイトル | Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning. |
| ジャーナル | Cell Rep |
| Abstract |
Parkinson's disease causes the most profound loss of the aldehyde dehydrogenase 1A1-positive (ALDH1A1+) nigrostriatal dopaminergic neuron (nDAN) subpopulation. The connectivity and functionality of ALDH1A1+ nDANs, however, remain poorly understood. Here, we show in rodent brains that ALDH1A1+ nDANs project predominantly to the rostral dorsal striatum, from which they also receive most monosynaptic inputs, indicating extensive reciprocal innervations with the striatal spiny projection neurons (SPNs). Functionally, genetic ablation of ALDH1A1+ nDANs causes severe impairments in motor skill learning, along with a reduction in high-speed walking. While dopamine replacement therapy accelerated walking speed, it failed to improve motor skill learning in ALDH1A1+ nDAN-ablated mice. Altogether, our study provides a comprehensive whole-brain connectivity map and reveals a key physiological function of ALDH1A1+ nDANs in motor skill acquisition, suggesting the motor learning processes require ALDH1A1+ nDANs to integrate diverse presynaptic inputs and supply dopamine with dynamic precision. |
| 巻・号 | 28(5) |
| ページ | 1167-1181.e7 |
| 公開日 | 2019-7-30 |
| DOI | 10.1016/j.celrep.2019.06.095 |
| PII | S2211-1247(19)30881-2 |
| PMID | 31365862 |
| PMC | PMC6741442 |
| MeSH | Aldehyde Dehydrogenase 1 Family / genetics Aldehyde Dehydrogenase 1 Family / metabolism* Animals Corpus Striatum / cytology Corpus Striatum / metabolism* Dopamine / metabolism Dopaminergic Neurons / cytology Dopaminergic Neurons / metabolism* Learning* Mice Mice, Transgenic Retinal Dehydrogenase / genetics Retinal Dehydrogenase / metabolism* Substantia Nigra / metabolism* |
| IF | 7.815 |
| 引用数 | 5 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | B6N Mouse BAC clone (RDB07573) B6Ng01-066I24 |