RRC ID 57613
Author Zhang C, Qiao H, Guo W, Liu Y, Yang L, Liu Y, Jin B, Fu M, Wang G, Li W.
Title CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis.
Journal Cancer Lett
Abstract Head and neck squamous cell carcinoma (HNSCC) is one of the most lethal cancers mainly due to the high rate of metastasis. Here, we find that the expression level of CD100 in HNSCC is positively correlated with the T category, pathological grade and lymph node metastasis of the tumor. The level of soluble CD100 (sCD100) is highly increased in serum of HNSCC patients, and sCD100 markedly induces the epithelial-mesenchymal transition (EMT) of HNSCC through its receptor, Plexin-B1 (PlxnB1), and promotes the metastasis in a xenograft mouse model. Furthermore, sCD100 promotes the stabilization of Snail through the regulation of the Vav1-Rac1/RhoA-p21-activated kinase pathway for the induction of EMT. Anti-CD100 antibody abolishes the CD100-induced EMT and prevents the metastasis of HNSCC, and anti-CD100 antibody also increases the drug sensitivity of HNSCC. Taken together, our study shows for the first time that CD100 induces the EMT of HNSCC and promotes the metastasis, and CD100 would be a candidate as a novel prognostic biomarker and a potential therapeutic target for HNSCC.
Volume 455
Pages 1-13
Published 2019-7-28
DOI 10.1016/j.canlet.2019.04.013
PII S0304-3835(19)30238-1
PMID 30981760
MeSH Animals Antigens, CD / biosynthesis Antigens, CD / blood Antigens, CD / metabolism* Biomarkers, Tumor / biosynthesis Biomarkers, Tumor / blood Biomarkers, Tumor / metabolism Cell Line, Tumor Epithelial-Mesenchymal Transition Female Head and Neck Neoplasms / blood Head and Neck Neoplasms / metabolism* Head and Neck Neoplasms / pathology* Heterografts Humans Mice Mice, Inbred C57BL Mice, Knockout Mice, Nude Neoplasm Metastasis Neoplasm Staging Nerve Tissue Proteins / biosynthesis Nerve Tissue Proteins / metabolism* Receptors, Cell Surface / biosynthesis Receptors, Cell Surface / metabolism* Semaphorins / biosynthesis Semaphorins / blood Semaphorins / metabolism* Squamous Cell Carcinoma of Head and Neck / blood Squamous Cell Carcinoma of Head and Neck / metabolism* Squamous Cell Carcinoma of Head and Neck / pathology*
IF 6.508
Times Cited 0
Mice RBRC00753
Human and Animal Cells Sa3(RCB0980) HSQ89