| RRC ID |
57613
|
| Author |
Zhang C, Qiao H, Guo W, Liu Y, Yang L, Liu Y, Jin B, Fu M, Wang G, Li W.
|
| Title |
CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis.
|
| Journal |
Cancer Lett
|
| Abstract |
Head and neck squamous cell carcinoma (HNSCC) is one of the most lethal cancers mainly due to the high rate of metastasis. Here, we find that the expression level of CD100 in HNSCC is positively correlated with the T category, pathological grade and lymph node metastasis of the tumor. The level of soluble CD100 (sCD100) is highly increased in serum of HNSCC patients, and sCD100 markedly induces the epithelial-mesenchymal transition (EMT) of HNSCC through its receptor, Plexin-B1 (PlxnB1), and promotes the metastasis in a xenograft mouse model. Furthermore, sCD100 promotes the stabilization of Snail through the regulation of the Vav1-Rac1/RhoA-p21-activated kinase pathway for the induction of EMT. Anti-CD100 antibody abolishes the CD100-induced EMT and prevents the metastasis of HNSCC, and anti-CD100 antibody also increases the drug sensitivity of HNSCC. Taken together, our study shows for the first time that CD100 induces the EMT of HNSCC and promotes the metastasis, and CD100 would be a candidate as a novel prognostic biomarker and a potential therapeutic target for HNSCC.
|
| Volume |
455
|
| Pages |
1-13
|
| Published |
2019-7-28
|
| DOI |
10.1016/j.canlet.2019.04.013
|
| PII |
S0304-3835(19)30238-1
|
| PMID |
30981760
|
| MeSH |
Animals
Antigens, CD / biosynthesis
Antigens, CD / blood
Antigens, CD / metabolism*
Biomarkers, Tumor / biosynthesis
Biomarkers, Tumor / blood
Biomarkers, Tumor / metabolism
Cell Line, Tumor
Epithelial-Mesenchymal Transition
Female
Head and Neck Neoplasms / blood
Head and Neck Neoplasms / metabolism*
Head and Neck Neoplasms / pathology*
Heterografts
Humans
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Nude
Neoplasm Metastasis
Neoplasm Staging
Nerve Tissue Proteins / biosynthesis
Nerve Tissue Proteins / metabolism*
Receptors, Cell Surface / biosynthesis
Receptors, Cell Surface / metabolism*
Semaphorins / biosynthesis
Semaphorins / blood
Semaphorins / metabolism*
Squamous Cell Carcinoma of Head and Neck / blood
Squamous Cell Carcinoma of Head and Neck / metabolism*
Squamous Cell Carcinoma of Head and Neck / pathology*
|
| IF |
6.508
|
| Times Cited |
0
|
| Resource |
| Mice |
RBRC00753 |
| Human and Animal Cells |
Sa3(RCB0980)
HSQ89 |
