RRC ID 57652
Author Hayashi M, Yoshida K, Tang H, Sadaoka T, Kawabata A, Jasirwan C, Mori Y.
Title Characterization of the human herpesvirus 6A U23 gene.
Journal Virology
Abstract Human herpesvirus 6 (HHV-6), which replicates abundantly in T cells, belongs to the Roseolovirus genus within the betaherpesvirus subfamily. Members of the Roseolovirus genus encode seven unique genes, U20, U21, U23, U24, U24A, U26, and U100. The present study focused on one of these, U23, by analyzing the characteristics of its gene product in HHV-6A-infected cells. The results indicated that the U23 protein was expressed at the late phase of infection as a glycoprotein, but was not incorporated into virions, and mostly stayed within the trans Golgi network (TGN) in HHV-6A-infected cells. Furthermore, analysis using a U23-defective mutant virus showed that the gene is nonessential for viral replication in vitro.
Volume 450-451
Pages 98-105
Published 2014-2-1
DOI 10.1016/j.virol.2013.12.004
PII S0042-6822(13)00667-3
PMID 24503071
MeSH Cell Line Gene Expression Regulation, Viral Glycoproteins / genetics Glycoproteins / metabolism* Herpesvirus 6, Human / genetics Herpesvirus 6, Human / growth & development Herpesvirus 6, Human / metabolism* Humans Protein Transport Roseolovirus Infections / metabolism Roseolovirus Infections / virology* Viral Proteins / genetics Viral Proteins / metabolism* trans-Golgi Network / metabolism trans-Golgi Network / virology
IF 2.819
Times Cited 6
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