論文 - 詳細
RRC ID | 57653 |
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著者 | Kawabata A, Serada S, Naka T, Mori Y. |
タイトル | Human herpesvirus 6 gM/gN complex interacts with v-SNARE in infected cells. |
ジャーナル | J Gen Virol |
Abstract |
Human herpesvirus 6 (HHV-6) glycoprotein M (gM) is an envelope glycoprotein that associates with glycoprotein N (gN), forming the gM/gN protein complex, in a similar manner to the other herpesviruses. Liquid chromatography-MS/MS analysis showed that the HHV-6 gM/gN complex interacts with the v-SNARE protein, vesicle-associated membrane protein 3 (VAMP3). VAMP3 colocalized with the gM/gN complex at the trans-Golgi network and other compartments, possibly the late endosome in HHV-6-infected cells, and its expression gradually increased during the late phase of virus infection. Finally, VAMP3 was incorporated into mature virions and may be transported with the gM/gN complex. |
巻・号 | 95(Pt 12) |
ページ | 2769-2777 |
公開日 | 2014-12-1 |
DOI | 10.1099/vir.0.069336-0 |
PMID | 25209806 |
MeSH | Cell Line Gene Expression Regulation / physiology HeLa Cells Herpesvirus 6, Human / metabolism* Humans Membrane Glycoproteins / genetics Membrane Glycoproteins / metabolism* Protein Binding T-Lymphocytes Vesicle-Associated Membrane Protein 3 / genetics Vesicle-Associated Membrane Protein 3 / metabolism* Viral Proteins / genetics Viral Proteins / metabolism* |
IF | 2.809 |
引用数 | 4 |
リソース情報 | |
研究用ヒト臍帯血幹細胞 |