RRC ID 57653
著者 Kawabata A, Serada S, Naka T, Mori Y.
タイトル Human herpesvirus 6 gM/gN complex interacts with v-SNARE in infected cells.
ジャーナル J Gen Virol
Abstract Human herpesvirus 6 (HHV-6) glycoprotein M (gM) is an envelope glycoprotein that associates with glycoprotein N (gN), forming the gM/gN protein complex, in a similar manner to the other herpesviruses. Liquid chromatography-MS/MS analysis showed that the HHV-6 gM/gN complex interacts with the v-SNARE protein, vesicle-associated membrane protein 3 (VAMP3). VAMP3 colocalized with the gM/gN complex at the trans-Golgi network and other compartments, possibly the late endosome in HHV-6-infected cells, and its expression gradually increased during the late phase of virus infection. Finally, VAMP3 was incorporated into mature virions and may be transported with the gM/gN complex.
巻・号 95(Pt 12)
ページ 2769-2777
公開日 2014-12-1
DOI 10.1099/vir.0.069336-0
PMID 25209806
MeSH Cell Line Gene Expression Regulation / physiology HeLa Cells Herpesvirus 6, Human / metabolism* Humans Membrane Glycoproteins / genetics Membrane Glycoproteins / metabolism* Protein Binding T-Lymphocytes Vesicle-Associated Membrane Protein 3 / genetics Vesicle-Associated Membrane Protein 3 / metabolism* Viral Proteins / genetics Viral Proteins / metabolism*
IF 2.809
引用数 4
リソース情報
研究用ヒト臍帯血幹細胞