Reference - Detail
| RRC ID | 57653 |
|---|---|
| Author | Kawabata A, Serada S, Naka T, Mori Y. |
| Title | Human herpesvirus 6 gM/gN complex interacts with v-SNARE in infected cells. |
| Journal | J Gen Virol |
| Abstract |
Human herpesvirus 6 (HHV-6) glycoprotein M (gM) is an envelope glycoprotein that associates with glycoprotein N (gN), forming the gM/gN protein complex, in a similar manner to the other herpesviruses. Liquid chromatography-MS/MS analysis showed that the HHV-6 gM/gN complex interacts with the v-SNARE protein, vesicle-associated membrane protein 3 (VAMP3). VAMP3 colocalized with the gM/gN complex at the trans-Golgi network and other compartments, possibly the late endosome in HHV-6-infected cells, and its expression gradually increased during the late phase of virus infection. Finally, VAMP3 was incorporated into mature virions and may be transported with the gM/gN complex. |
| Volume | 95(Pt 12) |
| Pages | 2769-2777 |
| Published | 2014-12-1 |
| DOI | 10.1099/vir.0.069336-0 |
| PMID | 25209806 |
| MeSH | Cell Line Gene Expression Regulation / physiology HeLa Cells Herpesvirus 6, Human / metabolism* Humans Membrane Glycoproteins / genetics Membrane Glycoproteins / metabolism* Protein Binding T-Lymphocytes Vesicle-Associated Membrane Protein 3 / genetics Vesicle-Associated Membrane Protein 3 / metabolism* Viral Proteins / genetics Viral Proteins / metabolism* |
| IF | 2.809 |
| Times Cited | 4 |
| Resource | |
| Cord blood stem cells for research | |