Reference - Detail
| RRC ID | 57671 |
|---|---|
| Author | Kojima N, Yoshida Y, Kurosawa N, Lee YC, Tsuji S. |
| Title | Enzymatic activity of a developmentally regulated member of the sialyltransferase family (STX): evidence for alpha 2,8-sialyltransferase activity toward N-linked oligosaccharides. |
| Journal | FEBS Lett |
| Abstract |
We have detected sialyltransferase activity of recombinant mouse STX, which was cloned from rat brain as a new member of the sialyltransferase family, but sialyltransferase activity of which had not been detected previously [Livingston and Paulson, J. Biol. Chem. (1993) 268, 11504-11507]. The activity of mouse STX was specific toward sialylated glycoproteins. N-Glycanase treatment and linkage-specific sialidase treatment of glycoproteins revealed that STX transfers sialic acids through alpha 2,8-linkages to only N-linked oligosaccharides of glycoproteins. However, polymerase activity for polysialic acid synthesis was not detected for this sialyltransferase. Since this alpha 2,8-sialyltransferase gene is highly restricted in fetal and newborn brain, it may be involved in the polysialylation of glycoproteins, especially of N-CAM. |
| Volume | 360(1) |
| Pages | 1-4 |
| Published | 1995-2-20 |
| DOI | 10.1016/0014-5793(95)00059-i |
| PII | 0014-5793(95)00059-I |
| PMID | 7875291 |
| MeSH | Animals Base Sequence Cloning, Molecular DNA, Complementary Gene Expression Regulation, Enzymologic* Mice Molecular Sequence Data Oligosaccharides / metabolism* Sialyltransferases / genetics Sialyltransferases / metabolism* |
| IF | 3.057 |
| Times Cited | 104 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | mST8SiaII (RDB02078) |