Reference - Detail
| RRC ID | 57689 |
|---|---|
| Author | Genovese S, Clément R, Gaultier C, Besse F, Narbonne-Reveau K, Daian F, Foppolo S, Luis NM, Maurange C. |
| Title | Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors. |
| Journal | Elife |
| Abstract |
It is still unclear what drives progression of childhood tumors. During Drosophila larval development, asymmetrically-dividing neural stem cells, called neuroblasts, progress through an intrinsic temporal patterning program that ensures cessation of divisions before adulthood. We previously showed that temporal patterning also delineates an early developmental window during which neuroblasts are susceptible to tumor initiation (Narbonne-Reveau et al., 2016). Using single-cell transcriptomics, clonal analysis and numerical modeling, we now identify a network of twenty larval temporal patterning genes that are redeployed within neuroblast tumors to trigger a robust hierarchical division scheme that perpetuates growth while inducing predictable cell heterogeneity. Along the hierarchy, temporal patterning genes define a differentiation trajectory that regulates glucose metabolism genes to determine the proliferative properties of tumor cells. Thus, partial redeployment of the temporal patterning program encoded in the cell of origin may govern the hierarchy, heterogeneity and growth properties of neural tumors with a developmental origin. |
| Volume | 8 |
| Published | 2019-9-30 |
| DOI | 10.7554/eLife.50375 |
| PII | 50375 |
| PMID | 31566561 |
| PMC | PMC6791719 |
| MeSH | Animals Asymmetric Cell Division / genetics* Body Patterning / genetics* Cell Differentiation / genetics Cell Proliferation / genetics* Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Gene Expression Regulation, Developmental Humans Larva / genetics* Larva / growth & development Neural Stem Cells / metabolism Neural Stem Cells / pathology Neurons / metabolism |
| IF | 7.08 |
| Times Cited | 0 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 65 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | DGRC#112622 |