論文 - 詳細
| RRC ID | 57739 |
|---|---|
| 著者 | Harada Y, Kizuka Y, Tokoro Y, Kondo K, Yagi H, Kato K, Inoue H, Taniguchi N, Maruyama I. |
| タイトル | N-glycome inheritance from cells to extracellular vesicles in B16 melanomas. |
| ジャーナル | FEBS Lett |
| Abstract |
We investigated the correlation between metastatic behaviors of tumor cells and asparagine-linked glycosylation (N-glycosylation) of tumor-derived extracellular vesicles (EVs). Three mouse melanoma B16 variants with distinct metastatic potentials show similar gene expression levels and enzymatic activities of glycosyltransferases involved in N-glycosylation. All melanoma variants and EVs have nearly identical profiles of de-sialylated N-glycans. The major de-sialylated N-glycan structures of cells and EVs are core-fucosylated, tetra-antennary N-glycans with β1,6-N-acetylglucosamine branches. A few N-glycans are extended by N-acetyllactosamine repeats. Sialylation of these N-glycans may generate cell-type-specific N-glycomes on EVs. Taken together, melanoma-derived EVs show high expression of tumor-associated N-glycans, and the core structure profile is inherited during multiple selection cycles of B16 melanomas and from tumor cells to EVs. |
| 巻・号 | 593(9) |
| ページ | 942-951 |
| 公開日 | 2019-5-1 |
| DOI | 10.1002/1873-3468.13377 |
| PMID | 30943309 |
| PMC | PMC6594130 |
| MeSH | Animals Extracellular Vesicles / metabolism* Glycosylation Glycosyltransferases / metabolism Melanoma, Experimental / pathology* Mice Nitrogen / metabolism* |
| IF | 3.057 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 10 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | B16/BL6(RCB2638) |