論文 - 詳細
| RRC ID | 57763 |
|---|---|
| 著者 | Kuwatani M, Kawakami H, Kubota Y, Kawakubo K, Ito YM, Togo S, Ikeda T, Kusama K, Kobayashi Y, Murata T, Sakamoto N. |
| タイトル | Verification of the effectiveness of fucosylated haptoglobin as a pancreatic cancer marker in clinical diagnosis. |
| ジャーナル | Pancreatology |
| Abstract |
BACKGROUND:Fucosylated haptoglobin detected by Pholiota squarrosa lectin (PhoSL) that had specificity for fucose α1-6 was reported as an effective biomarker for several gastrointestinal diseases. The aim of this study was to verify Fucosylated haptoglobin detected by Pholiota squarrosa lectin (PhoSL-HP) as a pancreatic cancer (PC) marker using a new method of PhoSL-ELISA. METHODS:PhoSL-HP in sera from 98 PC patients and 158 non-PC samples including 32 intraductal papillary mucinous neoplasm (IPMN) patients, 21 chronic pancreatitis (CP) patients and 105 non-pancreatic disease controls (NPDC) were measured. We compared sensitivities, specificities and areas under the curves (AUC) of PhoSL-HP, CA19-9 and CEA as single markers. We also evaluated PhoSL-HP as combination marker by comparing AUC of CA19-9 combined with PhoSL-HP or CEA. RESULTS:The sensitivities of PhoSL-HP, CA19-9 and CEA for PC were 58%, 76% and 42%, respectively. Although the specificity of PhoSL-HP for NPDC was inferior to both of CA19-9 and CEA, that for pancreatic diseases was higher than both of CA19-9 and CEA. Combined CA19-9 with PhoSL-HP, the AUC was significantly higher at 0.880 than single use of CA19-9 at 0.825 in case of distinguishing PC from other pancreatic diseases. In contrast, the AUC of CA19-9 was not elevated significantly when combined with CEA. CONCLUSION:PhoSL-HP would be a useful marker for PC and have sufficient complementarity for CA19-9. |
| 巻・号 | 19(4) |
| ページ | 569-577 |
| 公開日 | 2019-6-1 |
| DOI | 10.1016/j.pan.2019.04.007 |
| PII | S1424-3903(19)30095-X |
| PMID | 31031206 |
| MeSH | Adult Aged Aged, 80 and over Area Under Curve Biomarkers, Tumor / analysis* CA-19-9 Antigen / blood Carcinoembryonic Antigen / blood False Positive Reactions Female Fucose Haptoglobins / analysis* Humans Male Middle Aged Pancreatic Diseases / blood Pancreatic Diseases / diagnosis Pancreatic Neoplasms / blood* Pancreatic Neoplasms / diagnosis* Pancreatitis, Chronic / blood Pancreatitis, Chronic / diagnosis Reproducibility of Results Sensitivity and Specificity |
| IF | 3.241 |
| 引用数 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2 |