RRC ID |
57791
|
著者 |
Fuwa M, Shimazaki A, Mieda M, Yamashita N, Akaishi T, Taniguchi T, Kato M.
|
タイトル |
Efficacy and safety of the fixed combinations of tafluprost/timolol and latanoprost/carteolol.
|
ジャーナル |
Sci Rep
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Abstract |
In this study, we made a comparative efficacy and safety assessment of two different fixed combinations of drugs, viz., tafluprost/timolol (TAF/TIM) and latanoprost/carteolol (LAT/CAR), by determining their effects on intraocular pressure (IOP) in ocular normotensive monkeys and examining their toxic effects on ocular surface using human corneal epithelial cells. TAF/TIM was found to be more effective in lowering IOP for a longer duration compared to LAT/CAR. We found that the difference in the intensity of IOP-lowering effect was because of the differences in the strength of timolol compared with that of carteolol as a beta-adrenergic antagonist and strength of tafluprost compared with that of latanoprost as a prostaglandin analogue. In addition, TAF/TIM showed much less cytotoxic effects compared to LAT/CAR on the human corneal epithelial cells. Our findings showed that TAF/TIM is better than LAT/CAR with regard to the IOP-lowering effect in monkeys and toxicity on ocular surface.
|
巻・号 |
9(1)
|
ページ |
7491
|
公開日 |
2019-5-16
|
DOI |
10.1038/s41598-019-44028-2
|
PII |
10.1038/s41598-019-44028-2
|
PMID |
31097790
|
PMC |
PMC6522485
|
MeSH |
Animals
Antihypertensive Agents / administration & dosage
Antihypertensive Agents / adverse effects*
Antihypertensive Agents / pharmacology
Carteolol / administration & dosage
Carteolol / adverse effects*
Carteolol / pharmacology
Cell Line
Drug Combinations
Epithelium, Corneal / drug effects
Humans
Intraocular Pressure / drug effects*
Latanoprost / administration & dosage
Latanoprost / adverse effects*
Latanoprost / pharmacology
Macaca fascicularis
Male
Prostaglandins F / administration & dosage
Prostaglandins F / adverse effects*
Prostaglandins F / pharmacology
Timolol / administration & dosage
Timolol / adverse effects*
Timolol / pharmacology
|
IF |
3.998
|
引用数 |
2
|
リソース情報 |
ヒト・動物細胞 |
HCE-T(RCB2280) |