RRC ID 57791
著者 Fuwa M, Shimazaki A, Mieda M, Yamashita N, Akaishi T, Taniguchi T, Kato M.
タイトル Efficacy and safety of the fixed combinations of tafluprost/timolol and latanoprost/carteolol.
ジャーナル Sci Rep
Abstract In this study, we made a comparative efficacy and safety assessment of two different fixed combinations of drugs, viz., tafluprost/timolol (TAF/TIM) and latanoprost/carteolol (LAT/CAR), by determining their effects on intraocular pressure (IOP) in ocular normotensive monkeys and examining their toxic effects on ocular surface using human corneal epithelial cells. TAF/TIM was found to be more effective in lowering IOP for a longer duration compared to LAT/CAR. We found that the difference in the intensity of IOP-lowering effect was because of the differences in the strength of timolol compared with that of carteolol as a beta-adrenergic antagonist and strength of tafluprost compared with that of latanoprost as a prostaglandin analogue. In addition, TAF/TIM showed much less cytotoxic effects compared to LAT/CAR on the human corneal epithelial cells. Our findings showed that TAF/TIM is better than LAT/CAR with regard to the IOP-lowering effect in monkeys and toxicity on ocular surface.
巻・号 9(1)
ページ 7491
公開日 2019-5-16
DOI 10.1038/s41598-019-44028-2
PII 10.1038/s41598-019-44028-2
PMID 31097790
PMC PMC6522485
MeSH Animals Antihypertensive Agents / administration & dosage Antihypertensive Agents / adverse effects* Antihypertensive Agents / pharmacology Carteolol / administration & dosage Carteolol / adverse effects* Carteolol / pharmacology Cell Line Drug Combinations Epithelium, Corneal / drug effects Humans Intraocular Pressure / drug effects* Latanoprost / administration & dosage Latanoprost / adverse effects* Latanoprost / pharmacology Macaca fascicularis Male Prostaglandins F / administration & dosage Prostaglandins F / adverse effects* Prostaglandins F / pharmacology Timolol / administration & dosage Timolol / adverse effects* Timolol / pharmacology
IF 3.998
引用数 2
リソース情報
ヒト・動物細胞 HCE-T(RCB2280)