論文 - 詳細
| RRC ID | 57956 |
|---|---|
| 著者 | Ishiyama H, Yanagita RC, Takemoto K, Kobashi K, Sugiyama Y, Kawanami Y. |
| タイトル | Development of a d-allose-6-phosphate derivative with anti-proliferative activity against a human leukemia MOLT-4F cell line. |
| ジャーナル | Carbohydr Res |
| Abstract |
d-Allose, a C-3 epimer of d-glucose, is a naturally occurring rare monosaccharide that shows anti-proliferative activity against several human cancer cell lines. However, d-allose requires a relatively high concentration for the activity to be observed. Thus, developing more potent derivatives is needed for application. In cells, d-allose is converted to d-allose-6-phosphate (A6P), which is responsible for the anti-proliferative activity of d-allose. In this study, we synthesized A6P derivative 1 with biodegradable protecting groups, which showed higher anti-proliferative activity than A6P against a MOLT-4F human leukemia cell line. Similarly protected derivative of d-glucose-6-phosphate (G6P) (2) and tetraacetyl-A6P (3) showed weaker and less activity compared with 1, respectively, suggesting that both A6P moiety and the protecting group on the phosphate group are responsible for the activity. In addition, significantly weaker induction of thioredoxin-interacting protein (TXNIP) expression by 1 compared with d-allose suggests that 1 exhibited cytotoxicity through the synergetic effect of inducing TXNIP expression and other mechanisms. |
| 巻・号 | 487 |
| ページ | 107859 |
| 公開日 | 2020-1-1 |
| DOI | 10.1016/j.carres.2019.107859 |
| PII | S0008-6215(19)30401-X |
| PMID | 31751780 |
| MeSH | Antineoplastic Agents / chemical synthesis Antineoplastic Agents / chemistry Antineoplastic Agents / pharmacology* Cell Proliferation / drug effects Dose-Response Relationship, Drug Drug Development* Drug Screening Assays, Antitumor Humans Molecular Conformation Structure-Activity Relationship Tumor Cells, Cultured |
| IF | 1.841 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MOLT-4F(RCB1936) |