Reference - Detail
| RRC ID | 57975 |
|---|---|
| Author | Ito H, Matsushita S, Hyodo K, Tsurushima H, Sato Y, Sakakibara Y. |
| Title | Focusing on delayed clearance for identifying small-sized metastatic lung tumors using synchrotron radiation angiography with a highly sensitive receiver. |
| Journal | Gen Thorac Cardiovasc Surg |
| Abstract |
OBJECTIVES:To detect metastatic lung tumors of less than 1 mm in size by focusing on the clearance of contrast material using synchrotron radiation (SR) angiography characterized by high spatial resolution and high-sensitivity receiver. METHODS:C6 cells, derived from rat glioma cells, were injected to the rat tail vein. Two weeks after injection, the rats underwent SR angiography using a high-gain avalanche rushing amorphous photoconductor (HARP) receiver of extra-high sensitivity with high contrast resolution. The 256-grayscale value was employed in the analysis of images. RESULTS:19 nodules were identified in images. The tumors were confirmed histopathologically. The average tumor size was 621±193 µm. The clearance curve of the densities was expressed as a logarithm function. Tumors showed delayed clearance of contrast material, taking up to 28 s, compared with arteries, which cleared rapidly at 8 s. In 256 grayscale, the distance was 50. This gap in density clearance made it possible to identify tumors. CONCLUSIONS:SR angiography with a HARP receiver provides high sensitivity and spatial resolution and makes it possible to diagnose metastatic lung tumors of less than 1 mm in size by focusing on differences in the clearance times of contrast material. |
| Volume | 62(9) |
| Pages | 553-9 |
| Published | 2014-9-1 |
| DOI | 10.1007/s11748-014-0430-x |
| PMID | 25028092 |
| MeSH | Angiography / instrumentation Angiography / methods* Animals Contrast Media / pharmacokinetics* Lung Neoplasms / blood supply* Lung Neoplasms / diagnostic imaging* Lung Neoplasms / pathology Lung Neoplasms / secondary Male Radiographic Image Enhancement / methods Rats Rats, Wistar Selenium Synchrotrons |
| Resource | |
| Human and Animal Cells | C6(RCB2854) |